【発明の名称】10位置に置換基を持つ新ステロイド、それらの製造法及びそれらの薬剤としての使用

Japanese Patent JPH0772193

B2

A novel steroid of the formula I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carbocyclic aryl or heterocyclic aryl, R2 is methyl or ethyl, R3 is selected from the group consisting of optionally substituted alkyl of 1 to 8 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 8 carbon atoms, R4 is selected from the group consisting of hydrogen and acyl, is selected from the group consisting of R6 is selected from the group consisting of hydrogen and methyl, the wavy line indicates alpha or beta - and the dotted line in 1(2) indicates the optional presence of a second carbon-carbon bond and novel process and intermediates therefore having anti-glucocorticoid activity.

Jiyangjiyorujiyu touchi
The Elman Costruth
Vespelt Trelli
Daniel Huilibert

JP443686A

August 02, 1995

January 14, 1986

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Lucelle-Yukraf

A61K31/57; A61K31/575; A61K31/58; A61P3/04; A61P3/08; A61P3/10; A61P5/38; A61P9/10; A61K31/565; A61P9/12; A61P25/20; A61P27/02; A61P27/06; A61P29/00; A61P37/04; A61P43/00; C07J1/00; C07J3/00; C07J5/00; C07J7/00; C07J9/00; C07J17/00; C07J21/00; C07J31/00; C07J33/00; C07J41/00; C07J43/00; C07J51/00; H02J3/18; (IPC1-7): C07J3/00; A61K31/57; A61K31/575; A61K31/58; C07J5/00; C07J7/00; C07J9/00; C07J43/00

Motohiro Kurauchi (1 outside)

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