Title:
Use as substitution piperidine compounds and these orexin receptor regulation factors
Document Type and Number:
Japanese Patent JP6275814
Kind Code:
B2
Abstract:
The present invention is directed to compounds of Formula I: wherein X is CR1 or N; Y is CR2 or N; Z is NH or O; R1 is alkoxy, triazolyl, oxazolyl, isoxazolyl, oxadiazolyl, or pyrimidinyl; R2 is H, alkyl, or halo; R3 is H, alkyl, alkoxy, halo, triazolyl, oxazolyl, or pyrimidinyl; R4 is alkyl; R5 is pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl; wherein the pyridyl; benzoxazolyl; pyrimidinyl; pyridazinyl; quinoxalinyl; pyrazinyl; or quinazolinyl is optionally substituted with one or two substituents independently selected from the group consisting of alkyl, halo, or phenyl; and R6 is H or alkyl. Methods of making the compounds of Formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.
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Inventors:
Cote, Heather Earl.
Dvorak, Kurt A.
Preville, Cathy
Shaman, block tee.
Dvorak, Kurt A.
Preville, Cathy
Shaman, block tee.
Application Number:
JP2016501463A
Publication Date:
February 07, 2018
Filing Date:
March 12, 2014
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D401/12; A61K31/454; A61K31/4545; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/517; A61P1/04; A61P1/08; A61P1/12; A61P3/04; A61P3/06; A61P3/10; A61P9/06; A61P9/10; A61P9/12; A61P15/00; A61P19/02; A61P25/00; A61P25/04; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D401/14; C07D413/12; C07D413/14; C07D417/14
Foreign References:
| WO2009080533A1 | ||||
| WO2010048012A1 | ||||
| WO2008065626A2 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Uetake Yukiko
Yasuhito Suzuki