Title:
【発明の名称】生体内で哺乳類動物細胞の傷害を軽減させるための細胞透過性カルシウムバッファーの使用
Document Type and Number:
Japanese Patent JPH08502265
Kind Code:
A
Abstract:
A method of reducing the damaging effect of an injury to mammalian cells by treatment of the cell or mammalian tissue in vivo with a cell membrane permeant calcium buffer. The method comprises treating mammalian tissue with a damage reducing effective amount of the calcium buffer, preferably, a BAPTA derivative. The method may be used to control the concentration of Ca2+ ions in the vicinity of ion channel pores of the cells to prevent diffusion of toxic amounts of Ca2+ ions to subcellular sites located near the source of Ca2+ influx. The buffer treatment may be applied as a prophylactic or after the mammalian tissue has sustained injury.
Inventors:
Charlton, Milton, Pea
Tymiansky, michael
Tymiansky, michael
Application Number:
JP50947794A
Publication Date:
March 12, 1996
Filing Date:
October 14, 1993
Export Citation:
Assignee:
Charlton, Milton, Pea
Tymiansky, michael
Tymiansky, michael
International Classes:
C07D335/12; A61K31/00; A61K31/19; A61K31/195; A61K31/22; A61K31/335; A61K31/34; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/445; A61K45/00; A61P3/00; A61P3/14; A61P9/10; A61P25/00; A61P25/08; A61P43/00; C07D311/80; C07D339/08; (IPC1-7): A61K45/00; A61K31/38; A61K31/35; A61K31/195
Attorney, Agent or Firm:
Shigeru Yagita (1 outside)