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Title:
USE OF COMPOUND FOR PRODUCING MEDICINE EFFECTIVE FOR SUPPRESSING PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELL OF PULMONARY ARTERY
Document Type and Number:
Japanese Patent JP2007326873
Kind Code:
A
Abstract:

To provide a peptide having high biological and pharmacological activity as a therapeutic agent for the treatment of diseases relating to hypertension in the medical intervention involving dilation and remodeling of arterial blood vessel especially in pulmonary or systemic circulation.

The peptide comprises at least one specific highly conservative amino acid residue sequence expected to play an important role in connection with pulmonary and arteriolar hypertension. Known naturally occurring peptides "vasoactive intestinal peptide (VIP)" and "pituitary adenylate cyclase activating polypeptide (PACAP)" having these specific sequences are potent drugs successfully usable for the treatment of primary pulmonary hypertension (PPH), secondary pulmonary hypertension (SPH), and hypertension of the systemic circulation.

COPYRIGHT: (C)2008,JPO&INPIT


Inventors:
BLOCK LUTZ-HENNING
Application Number:
JP2007205383A
Publication Date:
December 20, 2007
Filing Date:
August 07, 2007
Export Citation:
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Assignee:
MONDOBIOTECH LICENSING OUT AG
International Classes:
A61K38/00; A61K38/22; A61P9/00; A61P9/04; A61P9/12; A61P11/00; A61P35/00; C07K7/06; C07K7/08; C07K14/00; C07K14/575
Foreign References:
US3898329A1975-08-05
WO2000005260A12000-02-03
Attorney, Agent or Firm:
浜野 孝雄
森田 哲二
平井 輝一