Title:
関節のMRI画像診断における造影増強剤としてポリニトロシル官能基を有するデンドリマーの利用
Document Type and Number:
Japanese Patent JP2004524259
Kind Code:
A
Abstract:
The image obtained by MR imaging of the joint of an animal, including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e.g, of Formula (I) wherein each R independently is either a nitroxyl group of Formula (II) wherein X is an oxygen atom or two hydrogen atoms, R' is lower alkyl and R'' is H or lower alkyl, or a group of Formula (III) wherein R''' is lower alkyl, or a group of Formula (IV); wherein each alkylene in Formulae (I), (III) and (IV) is a bridging divalent alkylene group of 2-6 carbon atoms with 2-3 carbon atoms in the chain and R is as defined herein, with the proviso that the total number of R groups in the molecule which are nitroxyl groups of Formula (II) is at least 6
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Inventors:
Rosen, Gerald M.
Application Number:
JP2001542817A
Publication Date:
August 12, 2004
Filing Date:
December 06, 2000
Export Citation:
Assignee:
Rosen, Gerald M.
International Classes:
C07D207/16; A61K49/00; A61K49/20; (IPC1-7): A61K49/00; C07D207/16
Domestic Patent References:
| JPS6094960A | 1985-05-28 | |||
| JP2002534409A | 2002-10-15 | |||
| JPS63501876A | 1988-07-28 | |||
| JPS6094960A | 1985-05-28 | |||
| JPS63500867A | 1988-03-31 | |||
| JP2002534409A | 2002-10-15 |
Other References:
JPN6010072770, Ｍａｃｒｏｍｏｌｅｃｕｌｅｓ, 19970616, ３０（１２）, ｐ．３６０６−３６１１
Attorney, Agent or Firm:
Kanji Arai
Naotaka Kono
Eiichiro Shimazaki
Naotaka Kono
Eiichiro Shimazaki