Title:
USE OF FUNGAL IMMUNOMODULATORY PROTEIN
Document Type and Number:
Japanese Patent JP2007084547
Kind Code:
A
Abstract:
To provide the use of a fungal immunomodulatory protein having an amino acid of sequence number 1: MSDTALIFRLAWDVKKLSFDYTPNWGRGNPNNFIDTVTFPKVLTDKAYTYRVAVSGRNLGVKPSYAVESDGSQKVNFLEYNSGYGIADTNTIQVFVVDPDTNNDFIIAQWN, or sequence number 3: SATSLTFQLAYLVKKIDFDYTPNWGRGTPSSYIDNLTFPKVLTDKKYSYRVVVNGSDLGVESNFAVTPSGGQTINFLQYNKGYGVADTKTIQVFVVIPDTGNSEEYIIAEWKKT in immunotherapy or reduction of glucose in the blood.
The use can be obtained from Ganoderma species, Flammulina velutipes or a recombinant microorganisms (e.g. a recombinant Escherichia coli or yeast).
Inventors:
CHEN TZU CHIH
KO JIUNN LIANG
KO JIUNN LIANG
Application Number:
JP2006256232A
Publication Date:
April 05, 2007
Filing Date:
September 21, 2006
Export Citation:
Assignee:
YEASTERN BIOTECH CO LTD
International Classes:
A61K38/00; A61K36/06; A61K38/16; A61P3/10; A61P35/00; A61P37/04; C07K14/375; C12N15/09
Domestic Patent References:
| JP2000270713A | 2000-10-03 | |||
| JP2005224205A | 2005-08-25 |
Foreign References:
| WO2005040375A1 | 2005-05-06 |
Other References:
JPN6012007633; ＫＯ，Ｊ．Ｌ． ｅｔ ａｌ: 'Ａ ｎｅｗ ｆｕｎｇａｌ ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ， ＦＩＰ-ｆｖｅ ｉｓｏｌａｔｅｄ ｆｒｏｍ ｔｈｅ ｅｄｉｂｌｅ ｍｕｓｈｒｏｏｍ， Ｆｌａｍｍｕｌｉｎａ ｖｅｌｕｔｉｐ' Ｅｕｒ Ｊ Ｂｉｏｃｈｅｍ Ｖｏｌ．２２８， Ｎｏ．２, 1995, ｐ．２４４-９
JPN6012007636; ＨＳＩＥＨ，Ｋ．Ｙ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｎ ｅｄｉｂｌｅ-ｍｕｓｈｒｏｏｍ-ｄｅｒｉｖｅｄ ｐｒｏｔｅｉｎ ｉｎｈｉｂｉｔｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｆｏｏｄ-ａｌｌｅｒｇｉｃ' Ｃｌｉｎ Ｅｘｐ Ａｌｌｅｒｇｙ Ｖｏｌ．３３， Ｎｏ．１１, 2003, ｐ．１５９５-６０２
JPN6012007625; ＬＩＮ，Ｗ．Ｈ． ｅｔ ａｌ: 'Ｄｉｍｅｒｉｚａｔｉｏｎ ｏｆ ｔｈｅ Ｎ-ｔｅｒｍｉｎａｌ ａｍｐｈｉｐａｔｈｉｃ ａｌｐｈａ-ｈｅｌｉｘ ｄｏｍａｉｎ ｏｆ ｔｈｅ ｆｕｎｇａｌ ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ' Ｊ Ｂｉｏｌ Ｃｈｅｍ Ｖｏｌ．２７２， Ｎｏ．３２, 1997, ｐ．２００４４-８
JPN6012007628; ＫＩＮＯ，Ｋ． ｅｔ ａｌ: 'Ａｎ ｉｍｍｕｎｏｍｏｄｕｌａｔｉｎｇ ｐｒｏｔｅｉｎ， Ｌｉｎｇ Ｚｈｉ-８ （ＬＺ-８） ｐｒｅｖｅｎｔｓ ｉｎｓｕｌｉｔｉｓ ｉｎ ｎｏｎ-ｏｂｅｓｅ ｄｉａｂｅｔｉｃ ｍｉｃｅ' Ｄｉａｂｅｔｏｌｏｇｉａ Ｖｏｌ．３３， Ｎｏ．１２, 1990, ｐ．７１３-８
JPN6012007631; 古庄律ら: '自然発症ならびに実験的糖尿病ラットにおける血糖制御，脂質代謝および細胞性免疫能に及ぼす桑葉添加食摂取' 日本食品保蔵科学会誌 Ｖｏｌ．３０， Ｎｏ．６, 2004, ２７１-６
JPN6012007633; ＫＯ，Ｊ．Ｌ． ｅｔ ａｌ: 'Ａ ｎｅｗ ｆｕｎｇａｌ ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ， ＦＩＰ-ｆｖｅ ｉｓｏｌａｔｅｄ ｆｒｏｍ ｔｈｅ ｅｄｉｂｌｅ ｍｕｓｈｒｏｏｍ， Ｆｌａｍｍｕｌｉｎａ ｖｅｌｕｔｉｐ' Ｅｕｒ Ｊ Ｂｉｏｃｈｅｍ Ｖｏｌ．２２８， Ｎｏ．２, 1995, ｐ．２４４-９
JPN6012007636; ＨＳＩＥＨ，Ｋ．Ｙ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｎ ｅｄｉｂｌｅ-ｍｕｓｈｒｏｏｍ-ｄｅｒｉｖｅｄ ｐｒｏｔｅｉｎ ｉｎｈｉｂｉｔｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｆｏｏｄ-ａｌｌｅｒｇｉｃ' Ｃｌｉｎ Ｅｘｐ Ａｌｌｅｒｇｙ Ｖｏｌ．３３， Ｎｏ．１１, 2003, ｐ．１５９５-６０２
JPN6012007636; ＨＳＩＥＨ，Ｋ．Ｙ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｎ ｅｄｉｂｌｅ-ｍｕｓｈｒｏｏｍ-ｄｅｒｉｖｅｄ ｐｒｏｔｅｉｎ ｉｎｈｉｂｉｔｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｆｏｏｄ-ａｌｌｅｒｇｉｃ' Ｃｌｉｎ Ｅｘｐ Ａｌｌｅｒｇｙ Ｖｏｌ．３３， Ｎｏ．１１, 2003, ｐ．１５９５-６０２
JPN6012007625; ＬＩＮ，Ｗ．Ｈ． ｅｔ ａｌ: 'Ｄｉｍｅｒｉｚａｔｉｏｎ ｏｆ ｔｈｅ Ｎ-ｔｅｒｍｉｎａｌ ａｍｐｈｉｐａｔｈｉｃ ａｌｐｈａ-ｈｅｌｉｘ ｄｏｍａｉｎ ｏｆ ｔｈｅ ｆｕｎｇａｌ ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ' Ｊ Ｂｉｏｌ Ｃｈｅｍ Ｖｏｌ．２７２， Ｎｏ．３２, 1997, ｐ．２００４４-８
JPN6012007628; ＫＩＮＯ，Ｋ． ｅｔ ａｌ: 'Ａｎ ｉｍｍｕｎｏｍｏｄｕｌａｔｉｎｇ ｐｒｏｔｅｉｎ， Ｌｉｎｇ Ｚｈｉ-８ （ＬＺ-８） ｐｒｅｖｅｎｔｓ ｉｎｓｕｌｉｔｉｓ ｉｎ ｎｏｎ-ｏｂｅｓｅ ｄｉａｂｅｔｉｃ ｍｉｃｅ' Ｄｉａｂｅｔｏｌｏｇｉａ Ｖｏｌ．３３， Ｎｏ．１２, 1990, ｐ．７１３-８
JPN6012007631; 古庄律ら: '自然発症ならびに実験的糖尿病ラットにおける血糖制御，脂質代謝および細胞性免疫能に及ぼす桑葉添加食摂取' 日本食品保蔵科学会誌 Ｖｏｌ．３０， Ｎｏ．６, 2004, ２７１-６
JPN6012007633; ＫＯ，Ｊ．Ｌ． ｅｔ ａｌ: 'Ａ ｎｅｗ ｆｕｎｇａｌ ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｐｒｏｔｅｉｎ， ＦＩＰ-ｆｖｅ ｉｓｏｌａｔｅｄ ｆｒｏｍ ｔｈｅ ｅｄｉｂｌｅ ｍｕｓｈｒｏｏｍ， Ｆｌａｍｍｕｌｉｎａ ｖｅｌｕｔｉｐ' Ｅｕｒ Ｊ Ｂｉｏｃｈｅｍ Ｖｏｌ．２２８， Ｎｏ．２, 1995, ｐ．２４４-９
JPN6012007636; ＨＳＩＥＨ，Ｋ．Ｙ． ｅｔ ａｌ: 'Ｏｒａｌ ａｄｍｉｎｉｓｔｒａｔｉｏｎ ｏｆ ａｎ ｅｄｉｂｌｅ-ｍｕｓｈｒｏｏｍ-ｄｅｒｉｖｅｄ ｐｒｏｔｅｉｎ ｉｎｈｉｂｉｔｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｆｏｏｄ-ａｌｌｅｒｇｉｃ' Ｃｌｉｎ Ｅｘｐ Ａｌｌｅｒｇｙ Ｖｏｌ．３３， Ｎｏ．１１, 2003, ｐ．１５９５-６０２
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro