Title:
感染状態の治療のためのグルココルチコイド受容体アンタゴニストの使用
Document Type and Number:
Japanese Patent JP2010500323
Kind Code:
A
Abstract:
The invention provides the use of a glucocorticoid receptor antagonist for the manufacture of a medicament for immune stimulation, such as prevention or treatment of infections or infectious conditions, in an aging mammalian subject, a mammalian subject with low serum DHEAS values, a mammalian subject with a high serum cortisol/DHEAS ratio or a mammalian subject with high neutrophil counts. In particular, the glucocorticoid receptor antagonist can be chosen from the group consisting of a dibenzopyranyl derivative defined and/or exemplified in US6329534 and WO200116128, mifepristone, and (11²,17²)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one.
Inventors:
Peter, BW M M Bernardous
Application Number:
JP2009523270A
Publication Date:
January 07, 2010
Filing Date:
August 06, 2007
Export Citation:
Assignee:
Narmrose Fuennault Chap Organon
International Classes:
A61K31/567; A61K31/58; A61P11/00; A61P13/02; A61P19/02; A61P31/04; A61P31/10; A61P31/12; A61P37/04; A61P43/00; C07J1/00; C07J17/00
Domestic Patent References:
| JP2005213156A | 2005-08-11 |
Foreign References:
| US5763433A | 1998-06-09 | |||
| WO1997037664A2 | 1997-10-16 |
Other References:
JPN5009015209; ＲＥＧＥＬＳＯＮ Ｗ: ＰＥＲＳＰＥＣＴＩＶＥＳ ＩＮ ＢＩＯＬＯＧＹ ＡＮＤ ＭＥＤＩＣＩＮＥ Ｖ３５ Ｎ３, 199204, Ｐ３３０-３３８
JPN6012054897; ＢＵＴＣＨＥＲ，Ｓ．Ｋ． ｅｔ ａｌ: Ａｇｉｎｇ ｃｅｌｌ Ｖｏｌ．４， Ｎｏ．６, 2005, ｐ．３１９-２４
JPN5009015210; ＴＨＯＭＳＯＮ Ｆ: ＪＯＵＲＮＡＬ ＯＦ ＡＦＦＥＣＴＩＶＥ ＤＩＳＯＲＤＥＲＳ Ｖ７８ Ｎ．ＳＵＰＰＬＥＭＥＮＴ １, 200403, Ｐ．Ｓ１３８
JPN6012054897; ＢＵＴＣＨＥＲ，Ｓ．Ｋ． ｅｔ ａｌ: Ａｇｉｎｇ ｃｅｌｌ Ｖｏｌ．４， Ｎｏ．６, 2005, ｐ．３１９-２４
JPN5009015210; ＴＨＯＭＳＯＮ Ｆ: ＪＯＵＲＮＡＬ ＯＦ ＡＦＦＥＣＴＩＶＥ ＤＩＳＯＲＤＥＲＳ Ｖ７８ Ｎ．ＳＵＰＰＬＥＭＥＮＴ １, 200403, Ｐ．Ｓ１３８
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura