To provide a method for preparation and identification of a polypeptide encoded by at least one murine genomic region or its human homolog involved in tumor development, and a method for diagnosis of cancers by using the genomic region.
There are provided murine genomic regions identified by retroviral insertional tagging of mice as being involved in tumor development, in particular leukemia development, as well as human homologues thereof, identification and development of anti-cancer drugs, such as small molecule inhibitors, antibodies, ribozymes, antisense molecules and RNA interference (RNAi) molecules, that are effective in reducing or eliminating the tumorigenic effects of genetic transformations in these genomic regions and/or eliminating the tumorigenic effects of their expression products, anti-cancer drugs, pharmaceutical composition, a method for cancer treatment using the pharmaceutical composition, especially methods of gene therapy, use of antibodies for cancer diagnosis, and a method for diagnosis of cancers by using the diagnostic composition.
DELWEL HENDRIK RUDOLF
LOWENBERG BOB
VALK PETER JACOBUS MARIA
Koichi Niimi