Title:
【発明の名称】眼神経障害治療のための神経栄養性因子刺激物質の使用
Document Type and Number:
Japanese Patent JP2002531405
Kind Code:
A
Abstract:
Compositions and methods for the treatment of retina and optic nerve head neuropathy are disclosed. The compositions and methods are particularly directed to the use of neurotrophic factor stimulators, such as AIT-082 (neotrofin), in the treatment of glaucomatous neuropathy.
Inventors:
Pan Rock-Hou
Application Number:
JP2000584892A
Publication Date:
September 24, 2002
Filing Date:
December 01, 1999
Export Citation:
Assignee:
Archon Laboratories, Inc.
International Classes:
A61K31/00; A61K31/122; A61K31/444; A61K31/454; A61K31/52; A61K31/592; A61K31/704; A61K45/00; A61P25/02; A61P27/02; A61P27/06; C07D213/22; C07D473/30; C07D235/26; C07J17/00; (IPC1-7): A61K45/00; A61K31/122; A61K31/444; A61K31/454; A61K31/52; A61K31/592; A61K31/704; A61P27/02; A61P27/06
Domestic Patent References:
| JPH10218787A | 1998-08-18 |
Foreign References:
| US5780450A | 1998-07-14 | |||
| WO1997019695A1 | 1997-06-05 | |||
| WO1998010785A1 | 1998-03-19 |
Other References:
L.D. AIMONE, ET AL: "The neurotrophic factor inducing vitamin D receptor ligand CB 1093 prevents acrylamide-induced neuro", SOCIETY FOR NEUROSCIENCE ABSTRACTS., vol. 23(1-2), JPN7010001904, 1997, pages 881, ISSN: 0001649906
山田恵子ら: "視力改善を示したnt11778遺伝子変異を持つレーベル視神経症の２家系", 臨眼, vol. ４７（１０）, JPN6010034150, 1993, pages 1739 - 1743, ISSN: 0001649900
平光忠久ら: "Idebenoneの網膜の過酸化脂質に対する抑制効果", あたらしい眼科, vol. ７（５）, JPN6010034151, 1990, pages 771 - 774, ISSN: 0001649901
NITTA A, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, vol. V349 N4, JPN5001023455, April 1994 (1994-04-01), pages 401 - 407, ISSN: 0001649902
ATSUMI NITTA ET AL,: "Clinical potential of compounds that stimulate nerve growth factor production. Contemporary Neurosc", NEUROPROTECTIVE SIGNAL TRANSDUCTION., JPN7010001903, 1998, pages 95 - 110, ISSN: 0001649903
MIDDLEMISS,P.J. ET AL: "AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC", NEUROSCI LETT, vol. 199, no. 2, JPN6010034152, 1995, pages 131 - 4, XP000904794, ISSN: 0001649904, DOI: 10.1016/0304-3940(95)12029-4
SEMKOVA,I. ET AL: "Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates g", BRAIN RES, vol. Vol.717, No.1-2, JPN6010034153, 1996, pages 44 - 54, ISSN: 0001649905
山田恵子ら: "視力改善を示したnt11778遺伝子変異を持つレーベル視神経症の２家系", 臨眼, vol. ４７（１０）, JPN6010034150, 1993, pages 1739 - 1743, ISSN: 0001649900
平光忠久ら: "Idebenoneの網膜の過酸化脂質に対する抑制効果", あたらしい眼科, vol. ７（５）, JPN6010034151, 1990, pages 771 - 774, ISSN: 0001649901
NITTA A, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, vol. V349 N4, JPN5001023455, April 1994 (1994-04-01), pages 401 - 407, ISSN: 0001649902
ATSUMI NITTA ET AL,: "Clinical potential of compounds that stimulate nerve growth factor production. Contemporary Neurosc", NEUROPROTECTIVE SIGNAL TRANSDUCTION., JPN7010001903, 1998, pages 95 - 110, ISSN: 0001649903
MIDDLEMISS,P.J. ET AL: "AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC", NEUROSCI LETT, vol. 199, no. 2, JPN6010034152, 1995, pages 131 - 4, XP000904794, ISSN: 0001649904, DOI: 10.1016/0304-3940(95)12029-4
SEMKOVA,I. ET AL: "Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates g", BRAIN RES, vol. Vol.717, No.1-2, JPN6010034153, 1996, pages 44 - 54, ISSN: 0001649905
Attorney, Agent or Firm:
Ryu Iwatani