USE OF PDE7 INHIBITORS FOR TREATMENT OF MOVEMENT DISORDERS

Title:

USE OF PDE7 INHIBITORS FOR TREATMENT OF MOVEMENT DISORDERS

Document Type and Number:

Japanese Patent JP2014198718

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide a use of PDE7 inhibitors for treatment of movement disorders.SOLUTION: Disclosed is a method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE & inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Inventors:

JOHN E BERGMANN
NEIL S CUTSHALL
GREGORY A DEMOPULOS
VINCENT A FLORIO
GEORGE GAITANARIS
PATRICK GRAY
HUFFMAN JOHN
RENE ONRUST
ZENG HONGKUI

Application Number:

JP2014109910A

Publication Date:

October 23, 2014

Filing Date:

May 28, 2014

Export Citation:

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Assignee:

OMEROS CORP

International Classes:

A61K45/00; A61K31/198; A61K31/433; A61K31/517; A61K31/519; A61K45/06; A61P25/14; A61P25/16; A61P43/00; C12N9/99; C12Q1/44; G01N33/15; G01N33/50

Domestic Patent References:

JP2004529123A	2004-09-24
JP2004510769A	2004-04-08
JP2005520801A	2005-07-14

Foreign References:

WO2003053975A1	2003-07-03
WO2003064389A1	2003-08-07

Other References:

JPN6015021277; ＮＡＴＵＲＥ　ＲＥＶＩＥＷＳ，　ＤＲＵＧ　ＤＩＳＣＯＶＥＲＹＶｏｌ．５，　Ｎｏ．８, 2006, ｐ．６６０-６７０
JPN6015021278; ＣｅｌｌＶｏｌ．１２３，　Ｎｏ．１, 2005, ｐ．２５-３５
JPN6015021279; Ｎｅｗ　Ｅｎｇｌａｎｄ　Ｊｏｕｒｎａｌ　ｏｆ　ＭｅｄｉｃｉｎｅＶｏｌ．３２５，　Ｎｏ．２１, 1991, ｐ．１４６８-１４７５

Attorney, Agent or Firm:

Shusaku Yamamoto
Natsuki Morishita

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