Title:
電子コンポーネントおよびペントピラノシルヌクレオシド接合体を製造するためのペントピラノシルヌクレオシドの使用
Document Type and Number:
Japanese Patent JP4674965
Kind Code:
B2
Abstract:
The invention relates to a process for preparing a conjugate that includes a pentopyranosyl nucleic acid and a biomolecule. The process includes the steps of providing a pentopyranosyl nucleic acid having at least two pentopyranosyl nucleotide subunits that are covalently linked between carbon 4 and carbon 2 of their respective pentopyranosyl rings. The pentopyranosyl nucleic acid also has an electrophilic reactive group. A biomolecule having a nucleophilic reactive group is also provided. The electrophilic reactive group of the pentopyranosyl nucleic acid and the nucleophilic reactive group of the biomolecule are reacted to form a covalent bond.
Inventors:
Mikulka, Christian
Windharp, Norbert
Brandstetter, Tillman
Burdinsky, Gerhard
Windharp, Norbert
Brandstetter, Tillman
Burdinsky, Gerhard
Application Number:
JP2000512846A
Publication Date:
April 20, 2011
Filing Date:
September 21, 1998
Export Citation:
Assignee:
Nanogen Recognomics Gaem Behr
International Classes:
C12Q1/68; A61K49/00; C07H1/00; C07H19/04; C07H19/067; C07H21/00; C07K16/00; C12N15/09; G01N33/532
Domestic Patent References:
| JP7508042A | ||||
| JP57146796A | ||||
| JP55153796A | ||||
| JP51024518A | ||||
| JP39002877A | ||||
| JP2001517674A | ||||
| JP2001517677A | ||||
| JP6234787A | ||||
| JP63101395A |
Foreign References:
| WO1997000882A1 | ||||
| WO1996012728A1 | ||||
| US4476301 | ||||
| US2993039 | ||||
| US2719843 | ||||
| US2644817 | ||||
| DE2027305A | ||||
| GB866815A | ||||
| GB690119A | ||||
| WO1997027317A1 |
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S. PITSCH,122. PYRANOSYL-RNA ('P-RNA'): BASE-PAIRING SELECTIVITY AND POTENTIAL TO REPLICATE,HELVETICA CHIMICA ACTA,スイス,1995年 9月 1日,V78N7,P1621-1635
B. DOBOSZEWSKI,SYNTHESIS OF 3'-DEOXY-3'-C-HYDROXYMETHYL-ALDOPENTOPYRANOSYL NUCLEOSIDES AND THEIR INCORPORATION INTO OLIGONUCLEOTIDES. PART 2.,TETRAHEDRON,1995年 9月15日,V51N45,P12319-12336
J.A. KELLEY,FURANOSE-PYRANOSE ISOMERIZATION OF REDUCED PYRIMIDINE AND CYCLIC UREA RIBOSIDES,JOURNAL OF MEDICINAL CHEMISTRY,米国,1986年11月 1日,V29N11,P2351-2358
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PERIGAUD,C. et al,Stereospecific synthesis of chiral acyclic analogs of guanosine,Bioorganic & Medicinal Chemistry Letters,1992年,Vol.2, No.7,p.677-80
GAGNIEU,C.H. et al,Synthesis, structure and reactivity with nucleophiles of β-L-arabinopyranose 1,2:3,4-disulfite,Carbohydrate Research,1988年,Vol.180, No.2,p.223-31
LERNER,L.M. et al,Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides,Journal of Medicinal Chemistry,1987年,Vol.30, No.8,p.1521-5
TAYLOR,M.D. et al,Ribose-modified adenosine analogs as adenosine receptor agonists,Journal of Medicinal Chemistry,1986年,Vol.29, No.3,p.346-53
GRANT,A.J. et al,Dialdehydes derived from adenine nucleosides as substrates and inhibitors of adenosine aminohydrolase,Biochemistry,1979年,Vol.18, No.13,p.2838-42
WALTON,E. et al,Indole and 4-aminoindole nucleosides,Journal of Organic Chemistry,1968年,Vol.33, No.7,p.192-7
DOBRYNIN,Y.V. et al,Study of the biological activity of indole nucleosides. Relation between structure and biological activity,Khimiko-Farmatsevticheskii Zhurnal,1978年,Vol.12, No.5,p.33-8
SOF'INA,Z.P. et al,Biological properties of indole nucleosides. II. Study of indole nucleosides in animals with transplanted tumors,Khimiko-Farmatsevticheskii Zhurnal,1978年,Vol.12, No.6,p.93-5
S. PITSCH,122. PYRANOSYL-RNA ('P-RNA'): BASE-PAIRING SELECTIVITY AND POTENTIAL TO REPLICATE,HELVETICA CHIMICA ACTA,スイス,1995年 9月 1日,V78N7,P1621-1635
B. DOBOSZEWSKI,SYNTHESIS OF 3'-DEOXY-3'-C-HYDROXYMETHYL-ALDOPENTOPYRANOSYL NUCLEOSIDES AND THEIR INCORPORATION INTO OLIGONUCLEOTIDES. PART 2.,TETRAHEDRON,1995年 9月15日,V51N45,P12319-12336
J.A. KELLEY,FURANOSE-PYRANOSE ISOMERIZATION OF REDUCED PYRIMIDINE AND CYCLIC UREA RIBOSIDES,JOURNAL OF MEDICINAL CHEMISTRY,米国,1986年11月 1日,V29N11,P2351-2358
M. MELGUIZO,A NEW ONE-STEP SYNTHESIS OF 8-AMINOPURINES NUCLEOSIDE ANALOG SFROM 6-(GLYCOSYLAMINO)-5-NITROSOPYRIMIDINES,JOURNAL OF ORGANIC CHEMISTRY,米国,1992年,V57N2,P559-565
I. SCHLOENVOGT,188. PYRANOSYL-RNA ('P-RNA'): NMR AND MOLECULAR DYNAMICS STUDY OFTHE DUPLEX FORMED BY SELF-PAIRING OF RIBOPYRANOSYL-(C-G-A-A-T-T-C-G),HELVETICA CHIMICA ACTA,スイス,1996年12月11日,V79N8,P2316-2345
PEREZ-PEREZ,M. et al,Stereospecific synthesis of pentopyranosyl analog of D4T monophosphate,Bioorganic & Medicinal Chemistry Letters,1994年,Vol.4, No.10,p.1199-202
PERIGAUD,C. et al,Stereospecific synthesis of chiral acyclic analogs of guanosine,Bioorganic & Medicinal Chemistry Letters,1992年,Vol.2, No.7,p.677-80
GAGNIEU,C.H. et al,Synthesis, structure and reactivity with nucleophiles of β-L-arabinopyranose 1,2:3,4-disulfite,Carbohydrate Research,1988年,Vol.180, No.2,p.223-31
LERNER,L.M. et al,Preparation and antileukemic screening of some new 6'-deoxyhexopyranosyladenine nucleosides,Journal of Medicinal Chemistry,1987年,Vol.30, No.8,p.1521-5
TAYLOR,M.D. et al,Ribose-modified adenosine analogs as adenosine receptor agonists,Journal of Medicinal Chemistry,1986年,Vol.29, No.3,p.346-53
GRANT,A.J. et al,Dialdehydes derived from adenine nucleosides as substrates and inhibitors of adenosine aminohydrolase,Biochemistry,1979年,Vol.18, No.13,p.2838-42
WALTON,E. et al,Indole and 4-aminoindole nucleosides,Journal of Organic Chemistry,1968年,Vol.33, No.7,p.192-7
DOBRYNIN,Y.V. et al,Study of the biological activity of indole nucleosides. Relation between structure and biological activity,Khimiko-Farmatsevticheskii Zhurnal,1978年,Vol.12, No.5,p.33-8
SOF'INA,Z.P. et al,Biological properties of indole nucleosides. II. Study of indole nucleosides in animals with transplanted tumors,Khimiko-Farmatsevticheskii Zhurnal,1978年,Vol.12, No.6,p.93-5
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Takako Koiso
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Takako Koiso