Title:
Use of the peptide complex for manufacture of prevention of alopecia, and the constituent for therapeutic measures
Document Type and Number:
Japanese Patent JP6149053
Kind Code:
B2
Abstract:
Use of specific peptides (I), or their conjugates (II), as enantiomers or diastereoisomers, also their mixtures, including racemates, optionally as a complex with zinc, to prepare a cosmetic or dermatological composition for preventative or curative treatment of alopecia, is new. Use of peptides of formula (I), or their conjugates of formula (II), as enantiomers or diastereoisomers, also their mixtures, including racemates, optionally as a complex with zinc, to prepare a cosmetic or dermatological composition for preventative or curative treatment of alopecia. X-Gly-His-Lys-Y (I) A-X-Gly-His-Lys-Y (II) A : radical of acid R-COOH (III), (dihydro)lipoic acid, N-lipoyl-lysine or retinoic acid; X : chain of 1-3 Lys, optionally methylated, or, in (II) may be a bond, or A-X is hydrogen; Y : hydroxy or amino; and R : 1-24C linear or branched aliphatic residue, optionally substituted by hydroxy and optionally containing 1-6 unsaturations. All amino acids have D, L or DL configuration. An independent claim is also included for a food supplement that contains (I) and (II), optionally together with a compound (X) that improves regrowth of hair. ACTIVITY : Dermatological. Anagen-phase mouse whisker follicles were cultured (by the method of J. Dermatol. Sci., 7 (1994) S55) in medium containing 10 -> 7> M of the peptide lipoyl-Lys-Gly-His-Lys-NH 2. Growth (no units stated) was 1.86 after 4 days; contrast 0.5 for a control without the peptide. MECHANISM OF ACTION : None given.
Inventors:
Pinel, Anne-Marie
Ochor, Michelle
Ochor, Michelle
Application Number:
JP2015022587A
Publication Date:
June 14, 2017
Filing Date:
February 06, 2015
Export Citation:
Assignee:
INSTITUT EUROPEEN DE BIOLOGIE CELLULAIRE
International Classes:
A61K38/00; A23L1/305; A23L33/00; A23L33/18; A61K8/64; A61K31/07; A61K31/122; A61K31/195; A61K31/202; A61K31/216; A61K31/4184; A61K31/455; A61K31/506; A61K31/53; A61K31/618; A61K38/06; A61K38/07; A61K38/08; A61K45/00; A61P17/14; A61Q7/00
Domestic Patent References:
| JP2000512613A | ||||
| JP61191694A | ||||
| JP2500367A | ||||
| JP6305941A | ||||
| JP2000500447A |
Foreign References:
| WO1995023580A1 | ||||
| WO2000058347A1 | ||||
| WO2003030860A1 |
Other References:
Journal of Investigative Dermatology,1999年,Vol.112,No.6,p957-964
Molecular Biology of the Cell,1995年,Vol.6,No.3,p327-343
Science,1993年,Vol.260,No.5108,p692-695
Development,1993年,Vol.119,No.4,p1041-1053
Biochemical Journal,1981年,Vol.199,No.3,p649-656
FEBS Letters,1988年,Vol.238,No.2,p343-346
Biochimica et Biophysica Acta,2001年,Vol.1526,No.2,p199-210
Enzyme and Microbial Technology,1993年,Vol.15,No.2,p167-172
Molecular Biology of the Cell,1995年,Vol.6,No.3,p327-343
Science,1993年,Vol.260,No.5108,p692-695
Development,1993年,Vol.119,No.4,p1041-1053
Biochemical Journal,1981年,Vol.199,No.3,p649-656
FEBS Letters,1988年,Vol.238,No.2,p343-346
Biochimica et Biophysica Acta,2001年,Vol.1526,No.2,p199-210
Enzyme and Microbial Technology,1993年,Vol.15,No.2,p167-172
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
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