Title:
神経根障害を処置するための所定薬剤の使用
Document Type and Number:
Japanese Patent JP4832641
Kind Code:
B2
Abstract:
The present invention relates to pharmaceutical compositions for the treatment of spinal disorders caused by the liberation of TNF-± comprising an effective amount of a TNF-± inhibitor, as well as methods for treatment of such disorders, and the use of TNF-± inhibitors in the preparation of pharmaceutical compositions for such treatment.
Inventors:
Olmarkel, Kjell
Lydebeek, Bjorn
Lydebeek, Bjorn
Application Number:
JP2000571927A
Publication Date:
December 07, 2011
Filing Date:
September 23, 1999
Export Citation:
Assignee:
Scienceicon arb
International Classes:
A61K31/65; A61K31/00; C07D215/22; A61K31/16; A61K31/165; A61K31/19; A61K31/33; A61K31/40; A61K31/44; A61K31/445; A61K31/495; A61K31/496; A61K31/50; A61K31/501; A61K31/522; A61K31/535; A61K31/56; A61K38/17; A61K38/55; A61K39/395; A61K45/00; A61K45/06; A61P25/00; A61P25/02; A61P37/00; A61P43/00; C07D213/22; C07D401/04; C07D473/06; C07D491/107; C07K16/28
Other References:
WEITHMANN,K.U. et al, Effects of tiaprofenic acid on urinary pyridinium crosslinks in adjuvant arthritic rats: comparison with doxycycline, Inflamm Res, 1997, Vol.46, No.7, p.246-52
MILANO,S. et al, Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood, Antimicrob Agents Chemother, 1997, Vol.41, No.1, p.117-21
SORBERA, L.A. et al, Etanercept, Drugs of the future, 1998 Sep, Vol.23, No.9, p.951-4
ONRUST,S.V. et al, Infliximab: a review of its use in Crohn's disease and rheumatoid arthritis, BioDrugs, 1998 Nov, Vol.10, No.5, p.397-422
SOMMER,C. et al, A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy, Neurosci Lett, 1997, Vol.237, No.1, p.45-8
SOMMER,C. et al, The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve, Pain, 1998 Jan, Vol.74, No.1, p.83-91
GOUPILLE,P. et al, The role of inflammation in disk herniation-associated radiculopathy, Semin Arthritis Rheum, 1998 Aug, Vol.28, No.1, p.60-71
OLMARKER,K. et al, Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury, Spine, 1998 Dec, Vol.23, No.23, p.2538-44
MILANO,S. et al, Intraperitoneal injection of tetracyclines protects mice from lethal endotoxemia downregulating inducible nitric oxide synthase in various organs and cytokine and nitrate secretion in blood, Antimicrob Agents Chemother, 1997, Vol.41, No.1, p.117-21
SORBERA, L.A. et al, Etanercept, Drugs of the future, 1998 Sep, Vol.23, No.9, p.951-4
ONRUST,S.V. et al, Infliximab: a review of its use in Crohn's disease and rheumatoid arthritis, BioDrugs, 1998 Nov, Vol.10, No.5, p.397-422
SOMMER,C. et al, A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy, Neurosci Lett, 1997, Vol.237, No.1, p.45-8
SOMMER,C. et al, The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve, Pain, 1998 Jan, Vol.74, No.1, p.83-91
GOUPILLE,P. et al, The role of inflammation in disk herniation-associated radiculopathy, Semin Arthritis Rheum, 1998 Aug, Vol.28, No.1, p.60-71
OLMARKER,K. et al, Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury, Spine, 1998 Dec, Vol.23, No.23, p.2538-44
Attorney, Agent or Firm:
Haruo Hamada