Title:
ヘプシジンによる鉄代謝を制御するためのTGF-βスーパーファミリーの化合物の調節因子の使用
Document Type and Number:
Japanese Patent JP5063366
Kind Code:
B2
Abstract:
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-² superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.
Inventors:
Lynn Herbert Wai.
Babbit Jody
Chun Raymond Tea.
Samad Talek A.
Schneeer Alan El.
Wolf Clifford
Babbit Jody
Chun Raymond Tea.
Samad Talek A.
Schneeer Alan El.
Wolf Clifford
Application Number:
JP2007556264A
Publication Date:
October 31, 2012
Filing Date:
February 16, 2006
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
A61K38/00; A61P7/06; A61P43/00; C07K14/47; C07K19/00; C12N15/09
Foreign References:
| CN1284380A | ||||
| WO2004092405A1 |
Other References:
Papanikolaou G et al.,Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis.,Nat Genet. ,2004年 1月,Vol.36 no.1,pp.77-82
Samad TA et al.,DRAGON, a bone morphogenetic protein co-receptor.,J Biol Chem.,2005年 1月25日,Vol.280 no.14,pp.14122-14129
Samad TA et al.,DRAGON, a bone morphogenetic protein co-receptor.,J Biol Chem.,2005年 1月25日,Vol.280 no.14,pp.14122-14129
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi