Title:
ニューロンの軸索退縮を予防するための幹細胞の使用
Document Type and Number:
Japanese Patent JP6539385
Kind Code:
B2
Abstract:
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.
Inventors:
Sara A. Bush
Kevin Pee. Horn
Robert W. Mays
Jerry silver
Kevin Pee. Horn
Robert W. Mays
Jerry silver
Application Number:
JP2018120714A
Publication Date:
July 03, 2019
Filing Date:
June 26, 2018
Export Citation:
Assignee:
ABT Holding Company
Case Western Reserve University
Case Western Reserve University
International Classes:
A61K35/30; A61K35/15; A61K35/28; A61K35/545; A61K45/00; A61P25/00; A61K35/12
Domestic Patent References:
| JP2006238875A | ||||
| JP10218787A | ||||
| JP2006117668A |
Foreign References:
| WO2007069666A1 | ||||
| WO2007087293A1 | ||||
| WO2008024996A1 |
Other References:
Experimental Neurology,2004年,Vol.189,p.231-240
Cell Transplantation,2007年,Vol.16,p.159-169
Cell Transplantation,2007年,Vol.16,p.159-169
Attorney, Agent or Firm:
Takeshi Oshio