Title:
Use of that as the extract, the extraction method, the proton pump down regulator, enzyme inhibitor, and the mucoprotective agent of Java Nikkei
Document Type and Number:
Japanese Patent JP5984853
Kind Code:
B2
Abstract:
Extract and/or fraction from Cinnamomum burmanii (DLBS2411) related to its extraction method and its biological activities show activities as antiulcer by conferring mucoprotection and down-regulating H+/K+ ATPase. Treatment with DLBS2411 decreases the H+/K+ ATPase mRNA level in HEK 293 and gastric parietal cells. In addition, DLBS2411 inhibits activity of H+/K+ ATPase gastric enzyme wherein pH influences this inhibition mechanism. DLBS2411 also has characteristic as antioxidant which is shown by the increase of reducing power as the given dosage increases.
Inventors:
Ali Fin, Poppy Filzani
Elle Way, Dizzy Deer Dowy
Yuliani, Veronica
James Nam, Sinanbella
Chandra Winata, Raymond Elle
Elle Way, Dizzy Deer Dowy
Yuliani, Veronica
James Nam, Sinanbella
Chandra Winata, Raymond Elle
Application Number:
JP2013557214A
Publication Date:
September 06, 2016
Filing Date:
March 09, 2012
Export Citation:
Assignee:
Percelo Ann Terbatas Dex Medica
International Classes:
A61K36/54; A61P1/04; A61P43/00
Domestic Patent References:
| JP58129002A | ||||
| JP59065018A | ||||
| JP2002187843A | ||||
| JP10175877A |
Foreign References:
| WO2010023572A1 | ||||
| WO2008059310A1 |
Other References:
Planta medica,1986年,No.6,p.440-443
天然薬物事典,1986年,p.134,136
Journal of Ethnopharmacology,2010年,Vol.128, No.2,p.537-540
世界有用植物事典,1989年,p.269 [C.burmanni]
天然薬物事典,1986年,p.134,136
Journal of Ethnopharmacology,2010年,Vol.128, No.2,p.537-540
世界有用植物事典,1989年,p.269 [C.burmanni]
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Noriko Tsujimoto
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Noriko Tsujimoto