USE OF THERAPEUTIC PEPTIDES FOR TREATMENT AND PREVENTION OF CANCER

Japanese Patent JP2015028034

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PROBLEM TO BE SOLVED: To provide a method for preventing, retarding, and reducing risks of initiation, growth and invasion of cancer.SOLUTION: MUC1 (DF3, CD227, episialin, PEM) is a heavily O-glycosylated heterodimeric protein of >300 kDa, normally expressed in a large amount on the apical surface of glandular epithelia. MUC1 mimetic peptides are administered to patients of mammary gland tumors, colon tumors and skin tumors. MUC1 mimetic peptides are fusion peptides of structure A-B-C or C-B-A where A is a protein transduction domain enhancing translocation of attached macromolecules across the cell membranes; B is a spacer of 0-5 amino acid residues; C is a polypeptide of 6-15 amino acid residues, where C comprises all or a portion of PYEKVSAGNGGSSLS(SEQ ID NO:1), and a portion of C comprises GGSSLS(SEQ ID NO:2).

WO/2020/161342	CODING RNA ADMINISTERED INTO THE SUPRACHOROIDAL SPACE IN THE TREATMENT OF OPHTALMIC DISEASES
JPH03206888	CHIMERIC MOUSE-HUMAN ANTIBODY WITH SPECIFICITY TO HIV ANTIGEN
JP2008514616	è¥æºã®æ²»çのたãã®çµåˆãçæ³

JOYCE A SCHROEDER

JP2014174796A

February 12, 2015

August 29, 2014

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ARISONA CANCER THERAPEUTICS LLC

A61K38/00; A61K31/517; A61K31/5377; A61K39/395; A61K45/00; A61P1/04; A61P15/00; A61P17/00; A61P35/00; A61P35/04

JP2008503498A	2008-02-07
JP2008500815A	2008-01-17

WO2006113667A1

2006-10-26

Spring water Original aim
Masao Haruna
Hirotaka Yamaguchi
Shun Osakabe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shin-ichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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