To provide a method for inhibiting tumor formation in a cancer patient at a site remote from sites of prior tumor formation and to a method for preventing metastases.
The methods involve administering to the cancer patient an inhibitor of vascular endothelial growth factor receptor 1+ bone marrow-derived cells under conditions effective either to inhibit tumor formation in the cancer patient at a site remote from sites of prior tumor formation or to prevent metastases. Candidate compounds useful for such purposes can be screened depending on whether they bind to vascular endothelial growth factor receptor 1+ bone marrow-derived cells comparing the level of vascular endothelial growth factor receptor 1+ bone marrow-derived cells to prior levels.
KAPLAN ROSANDRA N
RIBA REBECCA D
RAFII SHAHIN
| WO2003075841A2 | 2003-09-18 | |||
| WO1998022616A1 | 1998-05-28 | |||
| WO2002070008A1 | 2002-09-12 | |||
| WO2003006059A1 | 2003-01-23 | |||
| WO2003019136A2 | 2003-03-06 |
JPN6011035212; Ｎａｔｕｒｅ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．７， Ｎｏ．１１, 2001, ｐ．１１９４-１２０１
JPN7011002432; Ｗｕ ｅｔ ａｌ．: Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ａｓｓｏｃｉａｔｉｏｎ ｆｏｒ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．４３, 2002, ｐ．５２７
JPN6012005389; 耳展 Ｖｏｌ．４０， Ｎｏ．４, 1997, ｐ．３８６-３９４
Koichi Niimi