Title:
UTILIZATION OF CGRP ANTAGONIST IN TREATMENT OF PRURITUS AND OCULAR AND PALPEBRAL DYSESTHESIA
Document Type and Number:
Japanese Patent JP3024064
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To prepare a pharmaceutical and dermatological composition hardly causing side effects such as atrophy, hardly providing a fear of drug dependence by the chronical use and useful for treatment of ocular and palpebral pruritus, pain and dysesthesia by using a calcitonin gene related peptide antagonist.
SOLUTION: This pharmaceutical and dermatological composition contains (A) an antagonist of a calcitonin gene related peptide(CGRP) (e.g. CGRP8-37 and anti-CGRP antibody), and optionally (B) activating agents such as proteins (hydrolyzates), amino acids, polyhydric alcohols and vitamins, cicatrization agents, anti-allergic agents, etc. Preferably, the using amount of the component A based on the total weight of the composition is 0.000001-10 wt.%, preferably 0.0001-5 wt.%.
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Inventors:
Olivier de la Charlier
Lionel Briton
Lionel Briton
Application Number:
JP7277496A
Publication Date:
March 21, 2000
Filing Date:
March 27, 1996
Export Citation:
Assignee:
LOREAL
International Classes:
A61K8/00; A61K8/04; A61K8/11; A61K8/34; A61K8/40; A61K8/42; A61K8/60; A61K8/64; A61K9/08; A61K8/67; A61K8/68; A61K8/73; A61K8/92; A61K8/97; A61K36/00; A61K38/00; A61K38/22; A61K39/395; A61K45/00; A61P17/00; A61P27/02; A61P43/00; A61Q1/00; A61Q1/10; A61Q19/00; A61Q17/00; (IPC1-7): A61K7/48; A61K7/00; A61K9/08; A61K31/00; A61K35/78; A61K38/00; A61K39/395; A61K45/00
Other References:
Ｂｒ．Ｊ．Ｐｈａｒｍａｃｏｌ．，１１０，ｐ．７７２−７７６（１９９３）
Ｎｅｕｒｏｓｃｉｅｎｃｅ，４８［４］，ｐ．９６３−９６８（１９９２）
Ｎｅｕｒｏｓｃｉｅｎｃｅ，４８［４］，ｐ．９６３−９６８（１９９２）
Attorney, Agent or Firm:
Masatake Shiga