Title:
関節リウマチの新規遺伝因子としてのミエリン塩基性蛋白の利用
Document Type and Number:
Japanese Patent JP5565784
Kind Code:
B2
Abstract:
A novel genetic factor for rheumatoid arthritis is searched for and used as a diagnostic marker. A method of testing for rheumatoid arthritis, comprising detecting an autoantibody to myelin basic protein in a biological sample from a subject. A test kit for rheumatoid arthritis, comprising myelin basic protein. A diagnostic marker for rheumatoid arthritis, comprising an antibody to myelin basic protein. A method of judging the risk to develop rheumatoid arthritis, comprising identifying the single nucleotide polymorphism of a nucleotide present in the myelin basic protein gene of a subject or identifying the single nucleotide polymorphism of a nucleotide that is in linkage disequilibrium with the first mentioned nucleotide. A kit for judging the risk to develop rheumatoid arthritis, comprising nucleic acid probes and/or nucleic acid primers capable of detecting the single nucleotide polymorphism of a nucleotide present in the myelin basic protein gene of a subject or the single nucleotide polymorphism of a nucleotide that is in linkage disequilibrium with the first mentioned nucleotide. A method of screening for a substance effective as a prophylactic and/or therapeutic for rheumatoid arthritis, comprising adding a test substance to a myelin basic protein gene-expressing cell and then determining the expression level of the myelin basic protein gene or the gene product thereof.
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Inventors:
Fumihiko Matsuda
Mimori Keisei
Koichiro Omura
Chika Terao
Mimori Keisei
Koichiro Omura
Chika Terao
Application Number:
JP2013511015A
Publication Date:
August 06, 2014
Filing Date:
April 18, 2012
Export Citation:
Assignee:
Kyoto University
International Classes:
G01N33/53; C12Q1/68; G01N33/15; G01N33/50; G01N33/564; C12N15/09
Domestic Patent References:
| JP2010190898A | 2010-09-02 | |||
| JP2003512599A | 2003-04-02 | |||
| JP2007517019A | 2007-06-28 | |||
| JP2001139496A | 2001-05-22 | |||
| JP2003079270A | 2003-03-18 | |||
| JP2010190898A | 2010-09-02 | |||
| JP2003512599A | 2003-04-02 | |||
| JP2007517019A | 2007-06-28 | |||
| JP2001139496A | 2001-05-22 | |||
| JP2003079270A | 2003-03-18 |
Attorney, Agent or Firm:
Setuko Mayama
Kenichi Nomura
Kenichi Nomura
Previous Patent: JPS5565783
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