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Title:
UTILIZATION OF PHOSPHORIC ESTER AND PHOSPHONIC ESTER FOR TREATMENT OF RECOGNIZING FUNCTION DISEASE AND DEPRESSION
Document Type and Number:
Japanese Patent JPH07206883
Kind Code:
A
Abstract:

PURPOSE: To provide a novel compd. comprising a phosphoric ester having a pyrimidine ring and being useful as an effective component of a medicine for treating and preventing a recognizing function disease and emotional disorder, especially, an Alzheimer's disease, depression or the like.

CONSTITUTION: A novel phosphoric ester or phosphonic ester useful for treating and preventing a recognizing function disease, depression or the like is represented by formula I [wherein R is 1-6C alkyl; R1 is 1-6C alkyl or alkoxy; R2 is H, 1-6C alkyl, alkoxy, 3-7C cycloalkyl or the like; R3 is (substd.) 1-6C alkyl, (substd.) 1-6C alkoxy or H; R4 is halogen, 1-4C alkyl or alkoxy; and X is O or S], e.g. O-(6-methoxy-2-t-butyl-pyrimidin-4-yl)-O-methyl- thiomethanephosphonic diester. The compd. is obtained by reacting halogenated phosphonoyl or phosphoryl represented by formula II (wherein Hal is halogen) with 4-hydorxypyrimidine represented by formula III.


Inventors:
FURITSUTSU MAURAA
BERUNARUTO SHIYUMITSUTO
Application Number:
JP1994000332901
Publication Date:
August 08, 1995
Filing Date:
December 15, 1994
Export Citation:
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Assignee:
BAYER AG
TROPONWERKE GMBH & CO KG
International Classes:
C07D239/34; A61K31/505; A61K31/66; A61K31/675; C07D239/36; C07D239/52; C07F9/6512; (IPC1-7): C07F9/6512; A61K31/505; A61K31/66; C07D239/34; C07D239/36; C07D239/52
Attorney, Agent or Firm:
小田島 平吉