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Title:
VACCINE CONTAINING ALUMINUM ADJUVANT AND HISTIDINE
Document Type and Number:
Japanese Patent JP2009173681
Kind Code:
A
Abstract:

To provide the improvement in stability of vaccine containing an aluminum salt, especially the improvement in pH stability (buffer) and in adjuvant adsorption at various temperatures and/or the improvement in antigen stability (e.g. lowering of hydrolysis).

The above improvement is performed by providing a composition containing an antigen, the aluminum salt, and histidine and a process for producing the composition (including a step for mixing the antigen, the aluminum salt, and histidine). Amino acid histidine is used to improve the stability of vaccine containing the aluminum salt, can improve pH stability and adjuvant adsorption, and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminum salt. The antigen in vaccine may be a protein or a saccharide and is preferably from N. meningitidis.


Inventors:
CONTORNI MARIO
MAFFEI MASSIMO
Application Number:
JP2009115050A
Publication Date:
August 06, 2009
Filing Date:
May 11, 2009
Export Citation:
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Assignee:
CHIRON SRL
International Classes:
A61K39/09; A61K39/02; A61K39/05; A61K39/07; A61K39/08; A61K39/095; A61K39/10; A61K39/102; A61K39/106; A61K39/118; A61K39/13; A61K39/29; A61K39/39; A61K47/22; A61P31/00; A61P31/04; A61P31/20
Foreign References:
WO1999048525A11999-09-30
WO2000045841A22000-08-10
WO2000057906A12000-10-05
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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