ワクチンナノテクノロジー

Japanese Patent JP7029128

B2

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune response in T cells and/or in B cells, in some embodiments, comprising at least one immunomodulatory agent, and optionally comprising at least one targeting moiety and optionally at least one immunostimulatory agent. The invention provides pharmaceutical compositions comprising inventive vaccine nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive vaccine nanocarriers and pharmaceutical compositions thereof. The invention provides methods of prophylaxis and/or treatment of diseases, disorders, and conditions comprising administering at least one inventive vaccine nanocarrier to a subject in need thereof.

Ulrich Her. Von Andrian
Omid Sea. Farokazado
Robert S. Langer
Tobias Junt
Elliott Ashley Morseman
Chang Liang Fan
Pamela bust
Mateo Iannacon
Frank Alexis

JP2019172918A

March 03, 2022

September 24, 2019

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Massachusetts Institute of Technology
President and Fellows of Harvard College
The Brigham And Women's Hospital Incorporated
The Children's Medical Center Corporation

A61K38/18; A61K9/51; A61K31/203; A61K31/436; A61K39/00; A61K47/34; A61K47/59; A61P37/02; A61P37/08

J. Immunother., (2007.06), 30, [4], p.378-395
Trends Immunol., (2006), 27, [12], p.573-579
J. Immunother., (2006), 29, [2], p.165-174
薬学雑誌, (2007.02), 127, [2], p.301-306

Shusaku Yamamoto
Morishita Natsuki

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