Title:
アルツハイマー病治療用ワクチン
Document Type and Number:
Japanese Patent JP2011527681
Kind Code:
A
Abstract:
The invention provides a method for the treatment of a patient having a more severe form of Alzheimer's disease (AD), where the severe form of AD is characterized by pathogenic deposits of amyloid beta peptide (Aβ), comprising the administration of an immunogenic fragment of Aβ capable of inducing an immune response in the form of antibodies to specific to the pathogenic deposits of Aβ and, in particular, to neurotoxic forms of Aβ including N-terminally truncated forms of Aβ. The invention further provides a method for selecting a suitable immunogenic fragment of Aβ for the treatment of a more severe form of AD.
Inventors:
Savage, Mary Jei
Kinney, Gene Gee
Ryan, Xiaoping
Citron, Michael
Rosen, Laura Bee
Kinney, Gene Gee
Ryan, Xiaoping
Citron, Michael
Rosen, Laura Bee
Application Number:
JP2011517486A
Publication Date:
November 04, 2011
Filing Date:
July 02, 2009
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
A61K39/295; A61K38/00; A61K47/18; A61K47/48; A61P25/28; G01N33/15; G01N33/50; C07K14/47
Attorney, Agent or Firm:
Kawaguchi International Patent Office