Title:
Ｖａｌ、ＬｅｕおよびＩｌｅのメチル基の特異的同位体標識化のための方法
Document Type and Number:
Japanese Patent JP5752147
Kind Code:
B2
Abstract:
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR.
Inventors:
Guns pierre
Bois Vivier Jerome
Ayala Isabel
Amran Olivier
Bois Vivier Jerome
Ayala Isabel
Amran Olivier
Application Number:
JP2012547554A
Publication Date:
July 22, 2015
Filing Date:
January 06, 2010
Export Citation:
Assignee:
Comisaria Arenergy Atomique Eogene Luigi Arteana Teaf
ECOLE NORMALE SUPERIEURE
UNIVERSITE JOSEPH FOURIER
ECOLE NORMALE SUPERIEURE
UNIVERSITE JOSEPH FOURIER
International Classes:
C07B59/00; C07K1/13; C07C69/716; G01N24/08; G01R33/32
Foreign References:
| WO2000061525A1 |
Other References:
J. Am. Chem. Soc.,2003年11月12日,Vol.125, No.45,p.13868-13878
Biochemistry,1979年10月16日,Vol.18, No.21,p.4529-4531
Biochemistry,1979年10月16日,Vol.18, No.21,p.4529-4531
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office