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Title:
変異免疫グロブリン結合タンパク質
Document Type and Number:
Japanese Patent JP2005538693
Kind Code:
A
Abstract:
The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than glutamine or aspartic acid, which mutation confers an increased chemical stability at pH-values of up to about 13-14 compared to the parental molecule. The protein can for example be derived from a protein capable of binding to other regions of the immunoglobulin molecule than the complementarity determining regions (CDR), such as protein A, and preferably the B-domain of Staphylo-coccal protein A. The invention also relates to a matrix for affinity separation, which comprises an immunoglobulin-binding protein as ligand coupled to a solid support, in which protein ligand at least one asparagine residue has been mutated to an amino acid other than glutamine.

Inventors:
Hover, sofia
Application Number:
JP2003578408A
Publication Date:
December 22, 2005
Filing Date:
March 20, 2003
Export Citation:
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Assignee:
Amersham Biosciences Aktiebolag
International Classes:
B01J20/281; B01J20/24; C07K1/22; C07K14/31; C07K14/735; C07K16/00; C07K16/06; C07K19/00; C12N15/09; G01N30/88; (IPC1-7): C12N15/09; B01J20/24; C07K1/22; C07K14/31; C07K16/00; G01N30/48; G01N30/88
Attorney, Agent or Firm:
Kenichi Matsumoto
Hirokazu Ogura
Nobukazu Ito
Toshihisa Kurokawa