Title:
血管内皮増殖因子(VEGF)核酸リガンド複合体
Document Type and Number:
Japanese Patent JP3626503
Kind Code:
B2
Abstract:
This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.
Inventors:
Jangic, neboja
Gold, rally
Schmidt, Paul Gee
Chandra, Vargies
Willis, Michael
Gold, rally
Schmidt, Paul Gee
Chandra, Vargies
Willis, Michael
Application Number:
JP52055398A
Publication Date:
March 09, 2005
Filing Date:
October 17, 1997
Export Citation:
Assignee:
Guilleed Sciences, Inc.
International Classes:
C07H21/02; A61K31/7088; A61K31/712; A61K31/7125; A61K38/00; A61K45/00; A61K47/48; A61K48/00; A61K49/00; A61K49/18; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07H21/00; C07K14/52; C12N15/09; C12N15/115; C12N15/88; C12P19/34; C12Q1/68; (IPC1-7): C12N15/09; A61K31/7088; A61K38/00; A61K45/00; A61K49/00; A61P35/00
Other References:
Chemistry & Biology, 1995年,vol.2, no.10, p.683-695
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Shosuke Imai
Tadahiko Kurita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Shosuke Imai
Tadahiko Kurita