Title:
VASOPRESSIN RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JP2021014406
Kind Code:
A
Abstract:
To provide a compound that is highly water-soluble and has a vasopressin V2 receptor antagonistic action, which is particularly suitable for parenteral injections, and to provide a pharmaceutical containing said compound.SOLUTION: Provided are a compound having a vasopressin V2 receptor antagonistic action, represented by the compound of the following formula which is a representative example, and a pharmaceutical containing said compound. The pharmaceutical is useful as a prophylactic and/or therapeutic agent for fluid retention, edema, heart failure, ascites, pleural effusion, renal dysfunction, vasopressin secretion abnormality syndrome, liver cirrhosis, electrolyte disorder, polycystic kidney, cerebral stroke, hypertension, coronary artery disease or circulatory failure.SELECTED DRAWING: None
Inventors:
IWASAKI YOICHI
OKADA NAOKI
ITO NAOYA
UCHINO YUJIRO
NAGASAKA YOSUKE
MASAKI HIDEKAZU
OKADA NAOKI
ITO NAOYA
UCHINO YUJIRO
NAGASAKA YOSUKE
MASAKI HIDEKAZU
Application Number:
JP2017205709A
Publication Date:
February 12, 2021
Filing Date:
October 25, 2017
Export Citation:
Assignee:
TOA EIYO LTD
International Classes:
C07D215/08; A61K31/395; A61K31/439; A61K31/47; A61K31/55; A61K31/551; A61K31/5513; A61K31/5517; A61K31/553; A61K31/554; A61P1/16; A61P3/12; A61P5/10; A61P7/00; A61P7/10; A61P9/00; A61P9/04; A61P9/12; A61P13/12; A61P43/00; C07D215/22; C07D223/16; C07D225/06; C07D243/12; C07D243/14; C07D267/14; C07D281/10; C07D401/12; C07D403/06; C07D405/12; C07D409/12; C07D413/06; C07D471/04; C07D471/08; C07D487/04; C07D498/04
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation