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Title:
(-)-VENLAFAXINE DERIVATIVE, PRODUCTION METHOD AND USAGE THEREOF
Document Type and Number:
Japanese Patent JP2013256526
Kind Code:
A
Abstract:

To provide an optically pure (-)-venlafaxine derivative and a synthesis process thereof; and a composition containing the derivative and usage thereof.

Provided is a pharmaceutical composition consisting of a (-)-venlafaxine derivative essentially free of (+) stereoisomer or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Also, disclosed is a method for treatment and prevention of diseases and disorders including ( but not limited to ) affective disorders such as depression, bipolar disorder, mania, attentional deficit disorder, attentional deficit disorder accompanied by overactivity, Parkinson's disease, epilepsy, brain dysfunction, obesity and weight increase, incontinence, dementia and related disorders thereto.


Inventors:
Jerussi, Thomas P.
Senanayake, Chrisantha H.
Application Number:
JP2013000172984
Publication Date:
December 26, 2013
Filing Date:
August 23, 2013
Export Citation:
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Assignee:
SUNOVION PHARMACEUTICALS INC
International Classes:
A61K9/00; A61K31/135; A61K9/20; A61K9/48; A61K31/137; A61K31/277; A61K47/12; A61K47/26; A61K47/36; A61K47/38; A61P1/12; A61P1/14; A61P3/04; A61P7/02; A61P7/04; A61P9/10; A61P13/02; A61P15/00; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/36; A61P43/00; C07B57/00; C07C209/48; C07C209/68; C07C209/78; C07C209/88; C07C211/27; C07C215/64; C07C217/74
Domestic Patent References:
JPH0789851A1995-04-04
Foreign References:
WO1997040027A11997-10-30
Other References:
JPN6014034069; Br. J. Clin. Pharmacol. Vol.41, 1996, pp.149-156
JPN6014034064; Drug Development Research Vol.23, No.2, 1991, pp.191-199
JPN6014034065; Chirality Vol.4, 1992, pp.84-90
JPN6014034066; 日本化学会編: 季刊化学総説 光学異性体の分離 No.6, 19891010, 第2,16〜17,212〜213ページ, (株)学会出版センター
JPN6014034067; 月刊薬事 Vol.29, No.10, 198910, pp.2039-2042
JPN6014034068; ファルマシア Vol.25, No.4, 1989, pp.333-336
Attorney, Agent or Firm:
平木 祐輔
藤田 節
新井 栄一
田中 夏夫