Title:
VINYLATED DEOXYGUANOSINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3965455
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new derivative for production, etc., of antisenseologonucleotide having crosslink ability, which is a specific vinylated deoxyguanosine derivative, chemically stable and forms a covalent bond by reacting with a nucleophilic molecule such as cytidine.
SOLUTION: This new vinylated deoxyguanosine derivative (salt) is expressed by formula I {R1 is H; R2 is H, tert-butyldiphenylsilyl, a group expressed by formula II [R4 is H or di(p-methoxyphenyl)phenyl-methyl]; R3 is acetyl or R1 is methyl; R2 is tert-butyldiphenylsilyl; R3 is acetyl or R1 is trimethylsilyl; R2 is tert-butyldiphenylsilyl; R3 is H, acetyl or P(0) (OH)H} and useful as an intermediate for producing antisenseoligonucleic acid having crosslink ability. The compound is obtained by reacting a compound of formula III (TBDS is tert- butyldiphenylsilyl; X is a halogen; Ac is acetyl) with an allylmagnesium halide, etc.
Inventors:
Eiji history
Uemura Kengo
Nakajima Shoji
Minoru Maeda
Shigeki Sasaki
Uemura Kengo
Nakajima Shoji
Minoru Maeda
Shigeki Sasaki
Application Number:
JP22764895A
Publication Date:
August 29, 2007
Filing Date:
September 05, 1995
Export Citation:
Assignee:
Industry-University Collaboration Organization Kyushu
International Classes:
C07H19/073; C07H23/00; C07H19/10; (IPC1-7): C07H19/073; C07H19/10
Other References:
Tetrahedron Lett.,1995年 1月,Vol.36, No.3,421-424
日本薬学会第115年会講演要旨集2,社団法人日本薬学会,1995年 3月 5日,p.42
日本薬学会第115年会講演要旨集2,社団法人日本薬学会,1995年 3月 5日,p.42
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes
Masazumi Imamura
Toshio Shiozawa
Junji Kamata
Makoto Aihara
Masazumi Imamura
Toshio Shiozawa
Junji Kamata
Makoto Aihara
Previous Patent: PIERCED EARRING
Next Patent: CONTROLLING AGENT COMPOSITION FOR INSECT PEST OF CITRUS FRUITS AND CONTROLLING METHOD
Next Patent: CONTROLLING AGENT COMPOSITION FOR INSECT PEST OF CITRUS FRUITS AND CONTROLLING METHOD