Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
VINYLPYRROLIDINONE CEPHALOSPORIN DERIVATIVES
Document Type and Number:
Japanese Patent JPH10139783
Kind Code:
A
Abstract:

To obtain the subject new derivatives comprising specific vinylpyrrolidinone cephalosporin derivatives and useful for treatment and prevention, etc., of diseases due to gram-positive bacteria, especially sensitive and resistant staphylococcus, Pneumococcus and enteric coccus.

The new vinylpyrrolidinone cephalosporin derivatives are represented by formula I [R1 is a halogen, a (substituted)lower alkyl, a (substituted)phenyl, a (substituted)benzyl, a (substituted)heterocyclic group, etc.; R2 is H, OH, a lower alkyl-Qr (Q is an alkylene, CO or SO2; (r) is 0 or 1), an aryl-Qr, etc.; R3 is OH, a lower alkoxy, OM (M is an alkali metal), etc.; R4 and R5 are each H, a lower alkyl or phenyl; X is S, O, NH or CH2; (n) is 0, 1 or 2; (m) and (s) are each 0 or 1] and useful as a medicine, etc., for treatment and prevention of infectious diseases. The compound is obtained by treating a compound having formula II (Rf is H or trimethylsilyl; Rg is H, benzhydryl, etc.) with a carboxylic acid of formula III (Y is OH or its reactive derivative).


Inventors:
ANGEHRN PETER
HEINZE-KRAUSS INGRID
RICHTER HANS G F
Application Number:
JP30411597A
Publication Date:
May 26, 1998
Filing Date:
November 06, 1997
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/00; C07D501/06; C07D501/04; C07D501/14; C07D501/18; C07D501/24; C07D501/48; C07D501/50; C07D501/54; C07D501/56; (IPC1-7): C07D501/48; A61K31/545; C07D501/04; C07D501/54; C07D501/56
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)