Title:
VIRAL PARTICLE-LIKE CONSTRUCT, AND METHOD FOR FORMING THE SAME, UNDER PHYSIOLOGICAL CONDITION
Document Type and Number:
Japanese Patent JP2010207246
Kind Code:
A
Abstract:
To provide a new method for forming uniform viral particles under physiological conditions.
The method for forming uniform-sized viral particle aggregates composed of a viral protein includes incubating the viral protein, e.g. SV40 virus VP1 at pH 5.0-7.0 and at room temperature in the presence of 130-170 mM of sodium chloride and 1.5-2.5 mM of a divalent cation, and in the presence of a particle formation acceleration factor such as SV40 VP2. For encapsulation of a substance to be encapsulated in the viral protein particles, a substance to be encapsulated may be allowed to coexist during the incubation.
Inventors:
HANDA HIROSHI
NAKANISHI AKIRA
KAWANO MASAAKI
NAKANISHI AKIRA
KAWANO MASAAKI
Application Number:
JP2010135520A
Publication Date:
September 24, 2010
Filing Date:
June 14, 2010
Export Citation:
Assignee:
TOKYO INST TECH
International Classes:
C12N15/09; C07K14/025; C12N7/00
Domestic Patent References:
| JP2002360266A | 2002-12-17 | |||
| JP2002500637A | 2002-01-08 | |||
| JP2000511773A | 2000-09-12 |
Foreign References:
| WO2006004173A1 | 2006-01-12 | |||
| WO1991004330A1 | 1991-04-04 |
Other References:
JPN6013041422; Ｂｉｏｔｅｃｈｎｏｌ． Ａｐｐｌ． Ｂｉｏｃｈｅｍ． Ｖｏｌ．２９, 1999, ｐｐ．３１-４３
JPN6013041420; Ｊ． Ｖｉｒｏｌ． Ｖｏｌ．７３， Ｎｏ．５, 1999, ｐｐ．４４６５-４４６９
JPN6013041421; 日本病理学会会誌 Ｖｏｌ．９１， Ｎｏ．１, 2002, ｐ．２５３ Ｐ-１-２７９
JPN6014016697; Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｙ Ｖｏｌ．５１， Ｎｏ．２, 1984, ｐ．４５８-４６９
JPN6014016700; Ｃｅｌｌ Ｖｏｌ．３０, 1982, ｐｐ．１２３-１３０
JPN6014016703; Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｙ Ｖｏｌ．３５， Ｎｏ．２, 1980, ｐｐ．３７１-３８１
JPN6013041422; Ｂｉｏｔｅｃｈｎｏｌ． Ａｐｐｌ． Ｂｉｏｃｈｅｍ． Ｖｏｌ．２９, 1999, ｐｐ．３１-４３
JPN6013041420; Ｊ． Ｖｉｒｏｌ． Ｖｏｌ．７３， Ｎｏ．５, 1999, ｐｐ．４４６５-４４６９
JPN6013041421; 日本病理学会会誌 Ｖｏｌ．９１， Ｎｏ．１, 2002, ｐ．２５３ Ｐ-１-２７９
JPN6014016697; Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｙ Ｖｏｌ．５１， Ｎｏ．２, 1984, ｐ．４５８-４６９
JPN6014016700; Ｃｅｌｌ Ｖｏｌ．３０, 1982, ｐｐ．１２３-１３０
JPN6014016703; Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｙ Ｖｏｌ．３５， Ｎｏ．２, 1980, ｐｐ．３７１-３８１
JPN6013041422; Ｂｉｏｔｅｃｈｎｏｌ． Ａｐｐｌ． Ｂｉｏｃｈｅｍ． Ｖｏｌ．２９, 1999, ｐｐ．３１-４３
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
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