Title:
標的化されたヒト癌細胞において選択的に複製するウイルス変異体
Document Type and Number:
Japanese Patent JP2004536607
Kind Code:
A
Abstract:
Oncolytic viruses are described that have favorable anti-cancer activity and that are produced by random mutagenesis and subsequent bio-selection on cancer cells wherein the viruses are preferably adenoviruses having at least one mutation in the i-leader sequence of the viral major late transcriptional unit.
Inventors:
Shen, Eucao
Terry Harminston
Fatta ray, ant
Terry Harminston
Fatta ray, ant
Application Number:
JP2003515657A
Publication Date:
December 09, 2004
Filing Date:
July 09, 2002
Export Citation:
Assignee:
Onyx Pharmaceuticals, Incorporated
International Classes:
A61K31/711; A61K35/76; A61K35/761; A61K48/00; A61P35/00; A61P43/00; C07K14/075; C12N7/00; C12N7/01; C12N7/04; A61K38/00; (IPC1-7): C12N7/00; A61K35/76; A61K48/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita