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Title:
宿主細胞代謝経路の調節によるウイルス感染治療
Document Type and Number:
Japanese Patent JP2010538968
Kind Code:
A
Abstract:
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in "suicide" of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models.; Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.

Inventors:
Schenck, Thomas
Rabinowitz, Joshua Dee.
Muncher, Josh
Bennett, Bryson
Application Number:
JP2010510373A
Publication Date:
December 16, 2010
Filing Date:
June 02, 2008
Export Citation:
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Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY
International Classes:
A61K31/045; A61K31/085; A61K31/122; A61K31/136; A61K31/192; A61K31/194; A61K31/198; A61K31/216; A61K31/22; A61K31/222; A61K31/223; A61K31/265; A61K31/336; A61K31/341; A61K31/353; A61K31/365; A61K31/366; A61K31/381; A61K31/395; A61K31/4015; A61K31/403; A61K31/41; A61K31/416; A61K31/4178; A61K31/4196; A61K31/42; A61K31/421; A61K31/426; A61K31/427; A61K31/428; A61K31/44; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4706; A61K31/473; A61K31/496; A61K31/501; A61K31/506; A61K31/519; A61K31/52; A61K31/53; A61K31/5377; A61K31/661; A61K31/663; A61K31/7048; A61K31/7076; A61K45/00; A61P1/16; A61P31/12; A61P31/14; A61P31/16; A61P31/20; A61P31/22; A61P35/02; A61P43/00; C07K5/06
Domestic Patent References:
JPH02221269A1990-09-04
JPH09508370A1997-08-26
Foreign References:
US4602099A1986-07-22
US5190969A1993-03-02
Other References:
KAZUYOSHI IKUTA ET AL, VIROLOGY, vol. 154(1), JPN6013021712, 15 October 1986 (1986-10-15), pages 195 - 206, ISSN: 0002525258
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Masaru Nakajima