Title:
視覚機能再生剤又は視覚機能低下予防剤
Document Type and Number:
Japanese Patent JP6757024
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide an agent for regenerating a visual function or an agent for preventing the deterioration in a visual function, which has an excellent visual function regenerating ability. The agent for regenerating a visual function or the agent for preventing the deterioration in a visual function according to the present invention contains, as an active ingredient, a chimeric protein having both an amino acid sequence for a microorganism-origin ion-translocating receptor rhodopsin and an amino acid sequence for an animal-origin G-protein-conjugated receptor rhodopsin. The chimeric protein is preferably one in which an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the amino acid sequence for the microorganism-origin ion-translocating receptor rhodopsin is substituted by an amino acid sequence for a cytoplasm-side second loop and/or a cytoplasm-side third loop in the G-protein-conjugated receptor rhodopsin.
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Inventors:
Kurihara Toshihide
Yusaku Katata
Kunimi Yoko
K. Tsubota
Hideki Katori
Yusaku Katata
Kunimi Yoko
K. Tsubota
Hideki Katori
Application Number:
JP2018537436A
Publication Date:
September 16, 2020
Filing Date:
September 01, 2017
Export Citation:
Assignee:
Keio University
National Institute of Technology Nagoya Institute of Technology
National Institute of Technology Nagoya Institute of Technology
International Classes:
A61K48/00; A61K31/7088; A61K35/76; A61K38/16; A61P27/02; C12N15/864; C12N15/867
Domestic Patent References:
| JP2016519063A | ||||
| JP2009536219A |
Other References:
SASAKI, K. et al.,”Chimeric Proton-Pumping Rhodopsins Containing the Cytoplasmic Loop of Bovine Rhodopsin”,PLOS ONE,2014年 3月12日,Vol.9,No.3,e91323,P.1-12,[online], [検索日 2017.09.28],
Attorney, Agent or Firm:
Takeshi Komatani