Title:
ビタミンD類似体
Document Type and Number:
Japanese Patent JP3907010
Kind Code:
B2
Abstract:
The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R1 and R2 which may be the same or different, stand for hydrogen or C1-C5 hydrocarbyl; or R1 and R2, taken together with the carbon atom bearing the group X, can form a C3C8 carbocyclic ring; Q is methylene, ethylene, tri- or tetra-methylene and may optionally be substituted with an oxy group, -OR3, in which R3 is hydrogen, methyl or ethyl; Y is either a single bond or C1-C2 hydrocarbylene; and one or more carbons with in R1, R2, and/or Y may optionally be substituted with one or more fluorine atoms, or with a hydroxyl group. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.
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Inventors:
Culverly, Martin John
Henrik, Pedacen
Henrik, Pedacen
Application Number:
JP51993198A
Publication Date:
April 18, 2007
Filing Date:
October 27, 1997
Export Citation:
Assignee:
Leo Pharmaceutical Products Limited Actiesel Scab (Lebens Chemisque Fabric Production Actiesl Scab)
International Classes:
A61K31/59; A61P5/18; C07C401/00; A61P9/12; A61P17/00; A61P17/02; A61P17/10; A61P19/08; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P37/02
Domestic Patent References:
| JP5501718A | ||||
| JP4506965A | ||||
| JP9003040A | ||||
| JP7504903A | ||||
| JP6500089A | ||||
| JP7188281A |
Attorney, Agent or Firm:
Aoyama Aoi
Yasuo Shibata
Yasuo Shibata