Title:
肥満症の予防及び治療用ビタミンD類似体
Document Type and Number:
Japanese Patent JP2007512376
Kind Code:
A
Abstract:
Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin D3 or 1α,25-dihydroxyvitamin D2 or a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R1, R2, and R3 have the values described herein.
Inventors:
Krugetto Dame Margaret
Deluca Hector F
Arlens Jamie M
Ntambi James M
Thomson Brian
Deluca Hector F
Arlens Jamie M
Ntambi James M
Thomson Brian
Application Number:
JP2006541728A
Publication Date:
May 17, 2007
Filing Date:
November 24, 2004
Export Citation:
Assignee:
Wisconsin Alumni Research Foundation
International Classes:
A61K31/59; A61K31/592; A61K31/593; A61P1/16; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P11/00; A61P19/02; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama