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Title:
ビタミンDおよびステロイド誘導体の合成用中間体およびその製造方法
Document Type and Number:
Japanese Patent JP4187437
Kind Code:
B2
Abstract:
A compound having the structure: wherein n is an integer from 1-5; each of R1 and R2 independently is optionally substituted C1-C6 alkyl; each of W and X is independently hydrogen or C1-C6 alkyl; Y is O, S or NR3 where R3 is hydrogen, C1-C6 alkyl or a protective group; and Z is a CD ring structure of the formula a steroid ring structure of the formula or a vitamin D structure of the formula wherein each of the structures of Z optionally have one or more protected or unprotected substituents and/or one or more protective groups, and wherein any ring of the structure of Z may optionally have one or more unsaturated bonds.

Inventors:
Horn, david ai
Kuboji Noboru
Hirofumi Suzuki
Hitoshi Shimizu
Application Number:
JP2001393683A
Publication Date:
November 26, 2008
Filing Date:
December 26, 2001
Export Citation:
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Assignee:
The Trustees of Columbia University in the City of New York
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07D303/22; C07J3/00; C07C41/03; C07C43/184; C07C319/14; C07C401/00; C07D301/28; C07D303/24; C07J7/00; C07J17/00; C07J51/00; C07C321/16
Domestic Patent References:
JP6256300A
JP6508121A
JP4913162A
Other References:
Synthesis of postulated metabolites of 1α,25-dihydroxy-22-oxavitamin D3,Kubodera, N. et. al.,Bioorganic & Medicinal Chemistry Letters,1994年,4(5),753-756
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi