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Title:
ビタミンD系列の22-エン-25-オキサ-誘導体,該化合物の製造法,該誘導体を含有する薬学的調剤ならびに薬剤としての該調剤の使用
Document Type and Number:
Japanese Patent JP3589664
Kind Code:
B2
Abstract:
PCT No. PCT/EP93/01735 Sec. 371 Date Mar. 16, 1995 Sec. 102(e) Date Mar. 16, 1995 PCT Filed Jun. 30, 1993 PCT Pub. No. WO94/00429 PCT Pub. Date Jan. 6, 199422-En-24-a-oxa derivatives in the vitamin D series of general formula I (I) in which R1, R2 and R4, independently of one another, each mean a hydrogen atom, an alkanoyl group with 1 to 9 carbon atoms or an aroyl group, R3 mean a hydrogen atom each or a linear or branched alkyl group each with 1 to 4 carbon atoms, a trifluoromethyl group each or a saturated or unsaturated carbocyclic or heterocyclic 3-, 4-, 5- or 6-membered ring formed together with the tertiary carbon atom, and X means an alkylene radical -(CH2)n-with n=1, 2 or 3, process for their production and their pharmaceutical use for treating hyperproliferative diseases are disclosed.

Inventors:
Steinmeier, Andreas
Kirsch, Geralt
Nef, Gunter
Schwarz, Katika
Tyroff-Ekat, route
Wiesinger, Herbert
Harvey, Martin
Application Number:
JP50206494A
Publication Date:
November 17, 2004
Filing Date:
June 30, 1993
Export Citation:
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Assignee:
Schering Aktiengesellschaft
International Classes:
A61K31/59; A61P3/02; A61P17/00; A61P29/00; A61P35/00; A61P35/02; A61P37/06; C07C401/00; C07F7/18; (IPC1-7): C07C401/00
Domestic Patent References:
JP8501531A
Foreign References:
EP0450743A2
WO1989010352A1
Attorney, Agent or Firm:
Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Einzel Felix-Reinhard
Reinhard Einsel