Title:
ビタミンD3誘導体、およびそれを用いる炎症性呼吸器疾患治療剤
Document Type and Number:
Japanese Patent JP3992297
Kind Code:
B2
Abstract:
Provided are vitamin D3 derivatives expressed by the following general formula Ä1Ü Äwherein, R1 and R2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R3 and R4 are each a hydrogen atom, a hydroxyl group, an acyloxy group, an alkyloxy group, an alkylthio group or an alkyl group which is optionally substituted; R5, R6, R7 and R8 are each a hydrogen atom, a hydroxyl group, an alkyl group or an acyloxy group; R9 is a hydrogen atom, a hydroxyl group, an alkyl group or an alkylthio group; R10 is a hydrogen atom, an alkyl group or an alkyloxy group; A and B are each a hydrogen atom, a hydroxyl group, or together express a single bond; X and Y express a carbonyl oxygen, or one of them is a hydrogen atom and the other is a hydroxyl group or an acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2Ü, and a method for manufacturing the derivatives. The compounds can be sued as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis and dermatitis.
Inventors:
Yuko Tanaka
Kiyoshi Taka
Kenji Manabe
Minoru Furuya
Tabe Masayasu
Seiichi Ishizuka
Hitotsugi
Hiroaki Mitsuhashi
Naoshi Kishimoto
Atsuo Hari
Sakuma Yasushi
Kiyoshi Taka
Kenji Manabe
Minoru Furuya
Tabe Masayasu
Seiichi Ishizuka
Hitotsugi
Hiroaki Mitsuhashi
Naoshi Kishimoto
Atsuo Hari
Sakuma Yasushi
Application Number:
JP50417599A
Publication Date:
October 17, 2007
Filing Date:
June 24, 1998
Export Citation:
Assignee:
Teijin Limited
International Classes:
C07C401/00; A61K31/59; A61P29/00; A61P35/00
Domestic Patent References:
| JP9506343A | ||||
| JP8053411A | ||||
| JP3504377A |
Attorney, Agent or Firm:
Hideko Mihara