VITAMIN D COMPOUND AND PREPARATION THEREOF - DUPHAR INTERNATIONAL RESEARCH BESLOTEN VENNOOTSHAP

Title:

VITAMIN D COMPOUND AND PREPARATION THEREOF

Document Type and Number:

Japanese Patent JP3633639

Kind Code:

B2

Abstract:

PURPOSE: To provide a novel vitamin D compound which may be satisfactorily obtained from easily usable or available starting materials and is useful in the treatment of autoimmune diseases, inflammatory diseases, diseases based on abnormal cell differentiation, or the like.
CONSTITUTION: The vitamin D compound of formula I (wherein R1 represents H or OH; R2 represents a 1-3C alkyl, hydroxy 1-3C alkyl, 1-2C alkoxymethyl, 2-3C alkenyl or 2-3C alkinyl; R3 has at least 3 atoms at the main chain and represents a straight or branched chain of a saturated or non-saturated aliphatic hydrocarbon group or a divalent oxahydrocarbon group having 3 to 5 carbon atoms which may be optionally substituted by one or more substituents selected form epoxy, F and OH; R4 represents a sec- or tert-3-6C alkyl or 3-6C cycloalkyl; A and B are each H, methyl or methylene formed together with), is provided. The compound of the formula I wherein R1 is OH is provided by reacting a compound of formula II (wherein R5 represents a protected OH; R6 represents a 1-6C alkyl) with a compound of formula III (wherein X represents Cl, Br or I; M represents Li or Mg; p is of 0 or 1).

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Inventors:

Jose P. Cestello
Antonio Mourinho
Jose El Mascareniyas
Sebastian Jean The Harquez
Jijan Zorg Drager
Gerhardus Day H. Dakestra
Jiyang-Paul van de Verde

Application Number:

JP18547893A

Publication Date:

March 30, 2005

Filing Date:

June 29, 1993

Export Citation:

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Assignee:

DUPHAR INTERNATIONAL RESEARCH BESLOTEN VENNOOTSHAP

International Classes:

A61K31/59; A61K8/34; A61K8/67; A61P3/02; A61Q19/00; A61Q19/08; C07C49/513; C07C401/00; (IPC1-7): C07C401/00; A61K7/00

Domestic Patent References:

JP4506965A
JP7508515A

Foreign References:

WO1992003414A1
WO1992012963A1
US5182393
WO1991015475A1
EP0521550A1

Attorney, Agent or Firm:

Heikichi Odashima

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