NEW MATERIAL: Compounds of formula I [X1 is H, an acyl; R is formula II- formula IV (X2 is H, an acyl; Y is an alkyl, aryl; when Y is methyl, both X1 and X2 are not H)].
USE: Useful for synthesis of hydroxylated derivative of vitamin D2.
PROCESS: A starting substance of aldehyde of formula V or formula VI is added with a side chain fragment to produce 5,7-dienesteroid of formula VII as a central intermediate. Next, the 5,7-diene is converted into a vitamin D skeleton, and the side chain is modified as required to obtain a compound of formula I.
Schnoes, Heinrich K.
Morzycki, Jacek W.
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