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Title:
VITAMIN D2 COMPOUND
Document Type and Number:
Japanese Patent JP02209863
Kind Code:
A
Abstract:

NEW MATERIAL: Compounds of formula I [X1 is H, an acyl; R is formula II- formula IV (X2 is H, an acyl; Y is an alkyl, aryl; when Y is methyl, both X1 and X2 are not H)].

USE: Useful for synthesis of hydroxylated derivative of vitamin D2.

PROCESS: A starting substance of aldehyde of formula V or formula VI is added with a side chain fragment to produce 5,7-dienesteroid of formula VII as a central intermediate. Next, the 5,7-diene is converted into a vitamin D skeleton, and the side chain is modified as required to obtain a compound of formula I.


Inventors:
Deluca, Hector F.
Schnoes, Heinrich K.
Morzycki, Jacek W.
Application Number:
JP1989000336824
Publication Date:
August 21, 1990
Filing Date:
December 27, 1989
Export Citation:
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Assignee:
WISCONSIN ALUMNI RES FOUND
International Classes:
A61K31/56; A61K31/58; A61K31/59; A61P3/02; A61P43/00; C07C67/00; C07C401/00; C07D317/18; C07D317/20; C07D317/22; C07D317/24; C07J1/00; C07J9/00; C07J17/00; C07J43/00; C07J53/00; C07J71/00; (IPC1-7): A61K31/59; C07C401/00; C07D317/18