Title:
VITRONECTIN RECEPTOR ANTAGONIST
Document Type and Number:
Japanese Patent JP2010006838
Kind Code:
A
Abstract:
To provide a more potent inhibitor for the vitronectin receptor than for the fibrinogen receptor.
This invention provides a compound of formula (I) which have pharmacological activity for the inhibition of the vitronectin receptor and is useful in the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporosis.
Inventors:
CALLAHAN JAMES FRANCIS
COUSINS RUSSELL DONOVAN
KEENAN RICHARD MCCULLOCK
KWON CHET
MILLER WILLIAM HENRY
UZINKAS IRENE NIJOLE
COUSINS RUSSELL DONOVAN
KEENAN RICHARD MCCULLOCK
KWON CHET
MILLER WILLIAM HENRY
UZINKAS IRENE NIJOLE
Application Number:
JP2009235447A
Publication Date:
January 14, 2010
Filing Date:
October 09, 2009
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORP
International Classes:
C07D223/00; A61K31/415; C07D401/12; A61K31/44; A61K31/445; A61K31/47; A61K31/4704; A61K31/4745; A61K31/495; A61K31/52; A61K31/55; A61K31/551; A61K33/243; A61K45/00; A61K45/06; A61P9/00; A61P9/10; A61P19/10; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07D223/16; C07D233/56; C07D233/64; C07D235/18; C07D235/22; C07D243/14; C07D401/00; C07D401/14; C07D403/12; C07D413/12; C07D417/12; C07D487/00
Domestic Patent References:
| JP4491072B2 | 2010-06-30 |
Foreign References:
| WO1996000574A1 | 1996-01-11 | |||
| WO1996000730A1 | 1996-01-11 | |||
| WO1996006087A1 | 1996-02-29 | |||
| WO1996026190A1 | 1996-08-29 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Mizuhara Masahiro
Hiroshi Yamazaki
Tadayuki Motoyama
Kenji Tomita
Nishino Mitsuru
Mizuhara Masahiro