Title:
ＷＴ１抗原ペプチドコンジュゲートワクチン
Document Type and Number:
Japanese Patent JP6495839
Kind Code:
B2
Abstract:
The present invention provides a compound represented by the formula (1):
wherein X a and Y a are each a single bond and the like,
cancer antigen peptide A is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues,
R 1 is a hydrogen atom, a group represented by the formula (2):
wherein X b and Y b are each a single bond and the like,
cancer antigen peptide B has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide consisting of 7 - 30 amino acid residues, or cancer antigen peptide C, and
cancer antigen peptide C has a sequence different from that of the cancer antigen peptide A, and is an MHC class I-restricted WT1 peptide or an MHC class II-restricted WT1 peptide, consisting of 7 - 30 amino acid residues containing one cysteine residue,
or a salt thereof, and the like.
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Inventors:
Lee, Changja
Hitoshi Saka
Nishio Yukihiro
Gotomasashi
Norio Nishihara
Yousuke Takanashi
Hitoshi Saka
Nishio Yukihiro
Gotomasashi
Norio Nishihara
Yousuke Takanashi
Application Number:
JP2016022512A
Publication Date:
April 03, 2019
Filing Date:
February 09, 2016
Export Citation:
Assignee:
Sumitomo Dainippon Pharma Co., Ltd.
Cancer Immunology Institute Co., Ltd.
Cancer Immunology Institute Co., Ltd.
International Classes:
C07K7/06; A61K39/00; A61P35/00; C07K7/08; C07K14/00
Domestic Patent References:
| JP11504635A | ||||
| JP2006280324A |
Foreign References:
| WO2002079253A1 | ||||
| WO2004063217A1 | ||||
| WO2009072610A1 | ||||
| WO2008081701A1 | ||||
| WO2012026309A1 | ||||
| WO2010123065A1 | ||||
| WO2007063903A1 |
Attorney, Agent or Firm:
Norihito Yamao
Michiko Matsutani
Sakurai Yoko
Michiko Matsutani
Sakurai Yoko