To provide a Wasabi (Japanese horseradish) leaf component composition which exhibits strong detoxication metabolizable enzyme induction activity to thereby improve the detoxication metabolizable function, further inhibits nephropathy caused by drugs and diabetes, and resultingly reduces the risk of cancer and life style related diseases, and food and drink and a drug containing the same.

The Wasabi leaf composition comprises a Wasabi leaf component composed of Wasabi leaves, horseradish leaves or their extract, and exhibits the action of inducing activation of the phase II detoxication metabolizable enzyme, and exhibits the action of inhibiting nephropathy. The food and drink and the drug contain this composition as the major component.