Title:
生物活性親油性化合物の水溶性組成物
Document Type and Number:
Japanese Patent JP2004521900
Kind Code:
A
Abstract:
Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X-OOC-[(CH 2 ) n -COO] m } p -Y(I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is ±(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.
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Inventors:
Henrik Boroy-Borrowski
Marianna Sichoska-Walker
P. Roy Walker
Marianna Sichoska-Walker
P. Roy Walker
Application Number:
JP2002562397A
Publication Date:
July 22, 2004
Filing Date:
January 31, 2002
Export Citation:
Assignee:
NATIONAL RESEARCH COUNCIL OF CANADA
International Classes:
A61K9/00; A61K9/14; A61K31/01; A61K31/015; A61K31/045; A61K31/047; A61K31/122; A61K31/355; A61K31/7048; A61K35/60; A61K36/18; A61K47/12; A61K47/28; A61K47/30; A61P31/10; (IPC1-7): A61K31/7048; A61K9/14; A61K31/01; A61K31/045; A61K31/122; A61K31/355; A61K35/60; A61K35/78; A61K47/12; A61K47/30; A61P31/10
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga