Title:
多作用基リガンドで安定化した水溶性ナノ粒子及びその製造方法
Document Type and Number:
Japanese Patent JP4402720
Kind Code:
B2
Abstract:
Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.
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Inventors:
Jung, Jin-Woo
Jun, Yung-Wook
Choi, Jin-Sill
Jun, Yung-Wook
Choi, Jin-Sill
Application Number:
JP2007529654A
Publication Date:
January 20, 2010
Filing Date:
September 30, 2004
Export Citation:
Assignee:
Industry-Academic Corporation Foundation, Yonsei University
International Classes:
B82B1/00; A61K9/14; A61K39/44; A61K47/02; A61K47/10; A61K47/32; A61K47/34; A61K47/48; A61K47/50; A61K49/00; A61K49/06; A61K49/08; A61K49/16; B22F9/30; B82B3/00; B82Y5/00; B82Y25/00; B82Y30/00; B82Y40/00; C01G49/02; C01G49/08; H01F1/00; H01F1/06; H01F1/11; H01F1/28; H01F1/44
Foreign References:
| WO1999018934A1 | ||||
| WO2004064109A1 | ||||
| WO2001019405A1 | ||||
| WO2002098364A1 | ||||
| US20030028071 | ||||
| WO2004108165A1 | ||||
| WO2005013897A1 | ||||
| US6333110 | ||||
| US20040058457 | ||||
| WO2004110619A1 | ||||
| WO2003072247A1 |
Attorney, Agent or Firm:
Kenzo Hara International Patent Office