WATER-SOLUBLE POLYSACCHARIDE ORIGINATING FROM YAMABUSHITAKE (FUNGUS) AND ANTITUMOR AGENT MAINLY CONTAINING THE SAME

Japanese Patent JPH05117303

A

PURPOSE:To obtain the subject neutral aqueous solution of polysaccharide which can be used as a major ingredient of an antitumor agent because of its high antitumor activity, by extraction of YAMABUSHITAKE, a fungus (Hericium erinaceum), or its treated product with an organic solvent, then subjecting the extract to ion-exchange treatment. CONSTITUTION:Fruit bodies of YAMABUSHITAKE are combined with an organic solvent such as ethanol, homogenized, allowed to stand one day to effect extraction. The extraction mixture is filtered with suction to remove the residue, the residue of organic solvent extraction is subjected to repeated filtration operations with physiological salt solution at 4 deg.C for 2 hours to filter off the residue, which is combined with an aqueous solvent such as hot water at 100 deg.C and extracted with boiling water under stirring for 3 hours. The extract is cooled down, centrifuged, the supernatant is combined ethanol to separate the precipitate. The extract is centrifuged after cooling, the supernatant is combined with ethanol to separate the precipitate, which is dialyzed in flowing water to collect the water-soluble fraction. Then, the fraction is subjected to anion-exchange chromatography to effect elution with water whereby the polysaccharide of high antitumor activity originating from YAMABUSHITAKE is obtained.

MIZUNO TAKU
ITO HITOSHI
MORI YOSHINOBU
SAKAMOTO HIDEKI
SUZUKI CHIHARU

JP30694291A

May 14, 1993

October 26, 1991

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MIZUNO TAKU
ITO HITOSHI
KAGOME KK
FUJI ABRASIVE WORKS

A61K31/715; A61K36/07; A61P35/00; C08B37/00; (IPC1-7): A61K31/715; A61K35/84; C08B37/00

Hiromasa Iriyama

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