Title:
光力学的療法用の水溶性ポルフィリン誘導体、及び、それらの使用並びに製造
Document Type and Number:
Japanese Patent JP4510440
Kind Code:
B2
Abstract:
The invention relates to the chemistry of biologically active compounds, namely, to a new method to prepare water-soluble porphyrin derivatives, particularly chlorin derivatives having general formulae (1). The compounds of the present invention are useful as photosensitizers, as drug substances and optionally in suitable drug products, for the photodynamic therapy of cancer, of infectious and other diseases, as well as for light irradiation treatments in other cases. B is a ring having the structure: where: R1=-CH=CH2, -CH(OAlk)CH3, -CHO, -C(O)CH3; -CH2CH3; -CH(Alk)CH(COAlk)2, -CH2CH(COAlk)2, -CH(Alk)CH2COAlk, -CH(Alk)CH2CH(OH)CH3, -CH2CH2CH(OH)CH3 R2=-CH3, -CHO, -CH(OH)Alk, -CH=CHAlk, CH2OH, CH2OAlk; R3=H or lower alkyl; G=hydrophilic organic amine (f.ex. N-methyl-D-glucamine and other amino-group containing carbohydrate derivatives, TRIS, aminoacids, oligopeptides). Alk=alkyl substituent.
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Inventors:
Nifangchev, Nikolai
Jashun Ski, Dmitry Buoy
Jashun Ski, Dmitry Buoy
Application Number:
JP2003502003A
Publication Date:
July 21, 2010
Filing Date:
May 31, 2002
Export Citation:
Assignee:
Serum Optech Industries, Inc.
International Classes:
C07D487/22; A61K31/409; A61K41/00; A61P31/00; A61P35/00
Foreign References:
| RU2144538A | ||||
| US5330741 |
Other References:
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ZHENG, G. et al.,J. Chem. Soc., Prekin Trans. 1,2000年,p.3113-3121
MA, L. et al.,Tetrahedron,1996年,Vol.52/No.3,p.849-860
OSUKA, A. et al.,Tetrahedron,1996年,Vol.52/No.12,p.4311-4326
GOMI, S. et al.,Heterocycles,1998年,Vol.48/No.11,p.2231-2243
ANDO, T. et al.,Agric. Biol. Chem.,1991年,Vol.55/No.9,p.2441-2443
ANDO, T. et al.,Tetrahedron Lett.,1991年,Vol.32/No.38,p.5107-5110
ZHENG, G. et al.,J. Chem. Soc., Prekin Trans. 1,2000年,p.3113-3121
MA, L. et al.,Tetrahedron,1996年,Vol.52/No.3,p.849-860
OSUKA, A. et al.,Tetrahedron,1996年,Vol.52/No.12,p.4311-4326
GOMI, S. et al.,Heterocycles,1998年,Vol.48/No.11,p.2231-2243
ANDO, T. et al.,Agric. Biol. Chem.,1991年,Vol.55/No.9,p.2441-2443
Attorney, Agent or Firm:
Takehiko Saito
Yasuyuki Hata
Yasuyuki Hata