Title:
WHITENING AGENT SCREENING METHOD, BONE-FORMING PROTEIN 4 INHIBITOR, COSMETICS, AND METHOD FOR MANUFACTURING COSMETICS
Document Type and Number:
Japanese Patent JP2021171036
Kind Code:
A
Abstract:
To provide a method for screening a substance useful as a whitening agent by utilizing a mechanism involved in suppressing differentiation and proliferation of melanocytes, a BMP-4 inhibitor as a whitening agent whose usefulness is confirmed by the screening method, and a cosmetic comprising the whitening agent whose usefulness is confirmed by the screening method.SOLUTION: A method of screening for whitening agents uses as an index, decrease in an expression level of melanocyte differentiation-inducing factor in cells exposed to a whitening agent candidate substance relative to the expression level of melanocyte differentiation-inducing factor in a control group in which cells are not exposed to the whitening agent candidate substance. A BMP-4 inhibitor includes at least one of a group consisting of a burnet extract, an aloe vera leaf extract, soymilk fermented liquid, a moth bean seed extract, a horse chestnut extract, a glycyrrhiza extract, and an Angelica keiskei leaf/stem extract. A cosmetic comprises a whitening agent candidate substance whose expression level of melanocyte differentiation-inducing factor is confirmed to be reduced by the whitening agent screening method.SELECTED DRAWING: Figure 2
Inventors:
UDA KEN
SASAKI KAICHI
HONMA TOSHIYUKI
SASAKI KAICHI
HONMA TOSHIYUKI
Application Number:
JP2020080784A
Publication Date:
November 01, 2021
Filing Date:
April 30, 2020
Export Citation:
Assignee:
FUJIFILM CORP
International Classes:
C12Q1/02; A61K8/9783; A61K8/99; A61Q1/02; A61Q1/12; A61Q17/04; A61Q19/00; A61Q19/02; A61Q19/10; G01N33/15; G01N33/50; G01N33/68
Attorney, Agent or Firm:
Patent Service Corporation Taiyo International Patent Office